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JoVE Journal Medicine
Optimisé méthode LC-MS/MS pour l’analyse de haut débit d’échantillons cliniques de Ivacaftor, ses principaux métabolites et Lumacaftor dans les fluides biologiques des patients atteints de fibrose kystique
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Optimisé méthode LC-MS/MS pour l’analyse de haut débit d’échantillons cliniques de Ivacaftor, ses principaux métabolites et Lumacaftor dans les fluides biologiques des patients atteints de fibrose kystique

Article DOI: 10.3791/56084-v • 06:14 min • October 15th, 2017
October 15th, 2017 •
1, 1, 1,2, 1
1Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 2Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University

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Combinaison Ivacaftor et ivacaftor-lumacaftor sont deux nouveaux médicaments CF. Cependant, il y a toujours un manque de compréhension sur leur pharmacocinétique/pharmacodynamique et pharmacologie. Nous présentons une technique HPLC-MS optimisée pour l’analyse simultanée d’ivacaftor et ses principaux métabolites et lumacaftor.

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Médecine numéro 128 Ivacaftor lumacaftor HPLC-MS la fibrose kystique plasma expectorations les liquides biologiques
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