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Oprettelse af en værdifuld efterligner af Alzheimers sygdom i rotte dyremodel af Intracerebroventricular injektion af sammensat Amyloid Beta Protein

Article DOI: 10.3791/56157-v • 08:28 min • July 29th, 2018
July 29th, 2018 •
*1,3,5, *1,3,4, *2, 2,3, 1,3,4, 1,3,4
1Institute of Traditional Chinese Medicine, Chengde Medical College, 2Shijiazhuang Obstetrics and Gynecology Hospital, 3Hebei Province Key Research Office of Traditional Chinese Medicine Against Dementia, 4Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, 5Institute of Basic Medical Research of Basic Medical School
* These authors contributed equally

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Dette er en protokol til at efterligne Alzheimers sygdom hos rotter ved evaluering af rumlig hukommelse værdiforringelse, neuronal patologiske ændringer, neuronal amyloid beta protein (Aβ) byrde, og neurofibrillary tangles sammenlægning, fremkaldt ved injektion af Aβ25-35 kombineret omdanne vækst faktor-B1 med aluminium titantrichlorid og rekombinant human.

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Adfærd sag 137 Amyloid beta protein 25-35 aluminium titantrichlorid rekombinant human omdanne vækst faktor-B1 sammensat Aβ Alzheimers sygdom model hukommelse værdiforringelse neuropatologiske amyloid beta protein byrde neurofibrillary tangles sammenlægning
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