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Journal / Genetics / Promotor Capture Hej-C: Høj opløsning,…
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Genetics

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Promotor Capture Hej-C
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Promotor Capture Hej-C: Høj opløsning, Genome-wide profilering af promotor interaktioner

Article DOI: 10.3791/57320-v • 10:16 min • June 28th, 2018
June 28th, 2018 •
*1, *1,2, 1,3, 1,4, 1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, 2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, 3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 4Bioinformatics Group, The Babraham Institute, Babraham Research Campus, 5Department of Biological Science, Florida State University
* These authors contributed equally

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DNA regulerende elementer, såsom smagsforstærkere, kontrollerer genekspression ved fysisk at kontakte target gen initiativtagere, ofte gennem langtrækkende kromosom vekselvirkninger der spænder over stor genomisk afstande. Promotor fange Hi-C (PCHi-C) identificerer betydningsfulde vekselvirkninger mellem projektledere og distale regioner, gør det muligt for tildelingen af potentielle regulerende sekvenser til deres mål gener.

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Genetik sag 136 3D genom organisation initiativtagere smagsforstærkere langtrækkende interaktioner Hi-C cis-regulerende elementer genome-wide association undersøgelse (GWAS) ikke-kodende sygdom varianter kromatin sløjfer CHiCAGO HiCUP
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