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Pomalidomür tabanlı homo-PROTACs tarafından E3 Ubiquitin ligase Cereblon kimyasal Inaktivasyonu

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

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Bu çalışma, bir pomalidomür bazlı sentez ve karakterizasyon açıklar, yeni bir yaklaşım olarak bir roman yaklaşımı ve E3 Ubiquitin ligaz cereblon (CRBN), thalidomür analogların hedefi bozulması teşvik etmek.

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Kimya sayı 147 CRBN PROTAC IMID pomalidomür Ubiquitin ligaz Multipl myelom proteasom
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