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22.5:

Anatomy of the Circulatory System

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Biology
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JoVE Core Biology
Anatomy of the Circulatory System

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The human circulatory system, a complex network of cylindrical vessels and a central pump, transports nutrients, gases, and wastes throughout the body via three divisions. Coronary, providing blood to the heart. Pulmonary, including the heart and lungs. And Systemic, to the rest of the body.

When blood leaves the veins of the systemic circuit, it enters the right atrium, an upper chamber of the heart, and then the right ventricle, a lower chamber.

From here, blood travels a short distance into the pulmonary circuit through the pulmonary artery to the lungs where it is oxygenated, and then transported back by the pulmonary vein to the opposite side of the heart, the left atrium. It then flows into the left ventricle, which due to a thicker wall can pump blood much farther through the major artery, the aorta, to the entire body.

The aorta branches off, first to the coronary arteries providing the coronary circuit with blood. And then into other smaller arteries that bring the blood to the systemic circuit. The carotid arteries to the brain. The brachial arteries to the arms. The thoracic arteries to the trunk and gut. And the iliac arteries to the legs.

These arteries divide into even smaller vessels called arterioles and then capillaries going deep into muscles and providing all cells in the body with oxygen and nutrients while removing waste products.

The smallest capillaries converge into venules and veins to return blood. The jugular vein from the brain and head. The superior vena cava from the upper body parts. And the inferior vena cava from the lower body parts. All converge back to the heart and lungs where gas is exchanged and waste is finally removed.

22.5:

Anatomy of the Circulatory System

The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.

Blood travels from the right atrium to the right ventricle of the heart through the tricuspid valve, then from the right ventricle to the pulmonary artery through the pulmonary valve. Pulmonary veins then carry the blood to the left atrium of the heart, from which it is carried to the left ventricle through the mitral valve. Finally, the left ventricle pumps blood to the aorta (the largest artery in the body) through the aortic valve.

Arteries, which carry blood away from the heart, split and get progressively smaller, becoming arterioles and eventually a series of capillaries, the sites of gas exchange. Capillaries converge to become larger venules, and eventually merge into veins, which bring blood back to the heart.

Double Circulation and the Pulmonary Circuit

Humans have a double circulatory system, in which blood travels through the heart twice via the pulmonary and systemic circuits. First, the heart receives deoxygenated blood in its right side and then pumps it to the nearby pulmonary circuit, the capillaries that are involved in gas exchange. Here, oxygen enters the blood, while carbon dioxide leaves the blood.

The blood is then returned for its second trip through the heart. After passing through the left of side of the heart, blood is pumped out to the entire body through the systemic circuit, all the way to the toes, the fingers, the head, and everywhere in between. The strength required for this task makes the left side of the heart much thicker than the right side, giving the heart a lopsided, non-symmetrical appearance.

Coronary Circulation

The right side of the heart receives deoxygenated blood. So, how does the heart get oxygenated blood? There is a network of arteries and veins surrounding the heart tissue in a crown-like manner that are together known as the coronary circuit. These bring oxygenated blood to the heart and carry deoxygenated blood away.

Capillaries vs. Venules

The walls of the blood vessels reflect their function. Capillary walls are very thin to facilitate gas exchange, whereas arteries and veins are thicker and more complex. Arteries are the thickest blood vessels and are very strong, with two additional layers of tissue (compared to capillaries) to accommodate the high pressure of blood pumped from the heart. Dilation and contraction of the muscle tissue of the arteries are regulated by hormones, directing blood to or from specific areas. Blood returns to the heart at a much lower pressure, so veins have walls that are much thinner than those of arteries.

Suggested Reading

Patwardhan, Kishor. “The History of the Discovery of Blood Circulation: Unrecognized Contributions of Ayurveda Masters.” Advances in Physiology Education 36, no. 2 (June 1, 2012): 77–82. [Source]

Golbidi, Saeid, and Ismail Laher. “Exercise and the Cardiovascular System.” Cardiology Research and Practice 2012 (2012). [Source]