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27.7: Matrix Proteoglycans and Glycoproteins

JoVE Core
Cell Biology

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Matrix Proteoglycans and Glycoproteins

27.7: Matrix Proteoglycans and Glycoproteins

Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can withstand the compression forces.

The two common examples of matrix glycoproteins are integrin, laminin, and fibronectin. Integral proteins, or integrins, as their name suggests, integrate completely into the membrane structure with their hydrophobic membrane-spanning regions interacting with the phospholipid bilayer's hydrophobic region. Integral proteins may serve as enzymes, as structural attachments for the cytoskeleton's fibers, or as part of the cell’s recognition sites. Collagen and proteoglycan are attached to fibronectin proteins, which are further attached to integrin proteins. For example, the bacterium Streptococcus pyogenes, which is known to cause strep throat and various other infections, attach to fibronectin present in the extracellular matrix of the cells lining the oropharynx. Laminins are important for cell migration, growth and differentiation. In association with type IV collagens, the laminins form an interconnected network that provides strength and flexibility to the basal lamina.

This text is adapted from:

 Openstax, Anatomy and physiology 2e, Section 4.3: Connective tissue supports and protects.

Openstax, Biology 2e, Section 5.1: Components and Structure.

Openstax, Microbiology, Section 3.4: Unique characteristics of Eukaryotic cells.


Matrix Proteoglycans Glycosylated Proteins Extracellular Matrix Collagen Fibers Hyaline Cartilage Negative Charges Cations Water Molecules Gel-like Structure Compression Forces Matrix Glycoproteins Integrin Laminin Fibronectin Integral Proteins Membrane Structure Phospholipid Bilayer Enzymes Structural Attachments Cell Recognition Sites Streptococcus Pyogenes Fibronectin Proteins Cell Migration Growth And Differentiation

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