Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove

27.8: Role of Matrix Metalloproteases in Degradation of ECM

JoVE Core
Cell Biology

A subscription to JoVE is required to view this content. Sign in or start your free trial.

Role of Matrix Metalloproteases in Degradation of ECM

27.8: Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.

A collagenase molecule can cleave collagens type I, II, and III at a three-fourths distance from the N-terminal and digest several other ECM and non-ECM molecules.

The expression of MMPs is usually maintained at low levels in the body. Only when required, is MMP's activity modulated for local tissue remodeling. The activity of MMPs is regulated at several levels: regulation of gene expression, controlling the half-life of mRNA, and post-synthesis regulation, using other proteases and inhibitors. The MMPs are regulated by cytokines, growth factors, corticosteroids, retinoic acid, heparin, and interleukin-4.

MMPs help maintain tissue homeostasis and play an essential role in various physiological processes, such as bone remodeling, immunity, angiogenesis, and wound healing.

Suggested Reading


Matrix Metalloproteases MMPs Degradation Of ECM Hydrolysis Of Proteins Glycoproteins Extracellular Matrix Migration Of Cells Proliferation Of Cells Embryonic Development Morphogenesis Collagenase Collagen Deposition Morphogenesis Of Tadpoles Cleave Collagens Type I II III N-terminal ECM Molecules Gene Expression Regulation MRNA Half-life Control Post-synthesis Regulation Proteases And Inhibitors Cytokines Growth Factors Corticosteroids Retinoic Acid Heparin Interleukin-4 Tissue Homeostasis Bone Remodeling Immunity Angiogenesis Wound Healing

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter