Stroke continues to be a leading cause of death and long-term disability worldwide. Animal models are essential for investigating the mechanisms of stroke and exploring potential treatments and related complications. However, the reproducibility of traditional models and the development of novel ones are often hampered by a lack of visualized and standardized methodologies.

This Methods Collection will exclusively focus on methodological articles describing the development, refinement, or validation of conventional and innovative animal models of stroke and related disorders. Models may be based on any species, including rodents, rabbits, dogs, pigs, and non-human primates. We particularly welcome video articles that illustrate procedures for ischemic stroke, hemorrhagic stroke, cerebral venous thrombosis, post-stroke cognitive impairment, and post-stroke depression.

To ensure reproducibility, all submissions must include detailed technical information, including anesthesia induction, surgical procedures, and model validation. Comparative studies of different modeling approaches, imaging-guided procedures, and model optimizations are highly encouraged. We invite contributions from experts in preclinical stroke research, neuroscience, and experimental neurology.

By promoting methodological transparency and standardization, this collection aims to provide a practical, high-quality reference for researchers seeking reliable and suitable models. Furthermore, it will support reproducibility, enhance experimental consistency, and facilitate cross-laboratory comparisons in preclinical stroke research.