Lung Endothelium
Lung Endothelium - Related Videos
06:20
Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure
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Cited by 22 •
2011
This is a method to visualise leukocyte adhesion to the endothelium in harvested pressurised vessels. The technique enables studying vascular adhesion under shear flow with differing intraluminal pressures up to 200 mmHg thus mimic-ing the pathophysiological conditions of high blood pressure.
05:53
Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium
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Cited by 5 •
2016
After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.
12:50
Procedure for Lung Engineering
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Cited by 43 •
2011
We have developed a decellularized lung extracellular matrix and novel biomimetic bioreactor that can be used to generate functional lung tissue. By seeding cells into the matrix and culturing in the bioreactor, we generate tissue that demonstrates effective gas exchange when transplanted in vivo for short periods of time.
07:06
A Simple Method of Mouse Lung Intubation
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Cited by 50 •
2013
This paper describes a striaghforward and efficient method of intubating mice for pulmonary function measurements or pulmonary instillation, that allows the mice to recover and be studied at later times. The procedure involves an inexpensive fiberoptic light source that directly illuminates the trachea.
01:47
Lung Capacity
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2019
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures. There are four defined lung volume measures: tidal volume, inspiratory reserve volume, expiratory reserve volume, and residual volume. Tidal volume is the amount of air inhaled and exhaled in a normal breath. Inspiratory...
FAQs
Its selective barrier function controls how fluid and solutes move between circulating blood and lung tissue. This regulation helps maintain the conditions needed for gas exchange while limiting uncontrolled vascular permeability. When barrier control is disrupted, the resulting imbalance is relevant to pulmonary edema and other disorders involving abnormal fluid movement.
Cell adhesion and inflammatory signaling allow pulmonary endothelial cells to respond to local and circulating signals. These processes also coordinate interactions with immune cells and airway tissues, linking vascular behavior to pulmonary inflammation. Studying them helps explain how lung blood vessels participate actively in tissue responses rather than serving only as passive conduits.
The pulmonary endothelium helps coordinate blood flow across the pulmonary circulation while supporting the vascular conditions required for gas exchange. Its signaling and barrier activities connect circulation with lung tissue function. Consequently, endothelial changes can be examined when respiratory or cardiovascular disease involves altered pulmonary vascular behavior.
Interactions between pulmonary endothelial cells and platelets provide a biological context for thrombus formation within the lung circulation. Because the endothelium also regulates adhesion and vascular responses, changes in these relationships may influence thrombosis-related disease processes. This makes platelet-endothelial communication an important focus when investigating pulmonary vascular injury or dysfunction.
Researchers examine it when a disease involves pulmonary inflammation, edema, thrombosis, or vascular remodeling. The endothelium connects blood-borne signals with lung tissue and can therefore provide insight into how vascular changes affect respiratory and cardiovascular health. Its study is especially relevant when disease disrupts permeability, blood flow, or communication with immune and airway cells.
Investigating pulmonary endothelial structure and function can reveal how vascular permeability, cell adhesion, inflammatory pathways, and blood-flow coordination contribute to lung physiology. These observations help relate cellular behavior to larger outcomes such as impaired gas exchange, inflammation, edema, thrombosis, and vascular remodeling, providing a framework for interpreting respiratory and cardiovascular disease mechanisms.