Quartz Clamp
Quartz Clamp - Related Videos
02:58
Rodent Brain Microinjection Using a Quartz Microneedle
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2025
Source: Paolone, G., et al. Personalized Needles for Microinjections in the Rodent Brain. J. Vis. Exp. (2018).This video demonstrates a rodent brain microneedle injection using a quartz microneedle with holes. The microneedle is attached to a syringe and micropump to control the delivery rate. The needle with the injection solution is inserted into the brain with the delivery speed set at low. Once positioned, the delivery speed is increased. The needle is withdrawn after a brief pause.
07:37
Preparation of Macroporous Epitaxial Quartz Films on Silicon by Chemical Solution Deposition
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Cited by 7 •
2015
A protocol is presented for the preparation of piezoelectric macroporous epitaxial films of quartz on silicon by solution chemistry using dip-coating and thermal treatments in air.
09:43
Patch Clamp Electrophysiology
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2023
Neuron cell membranes are populated with ion channels that control the movement of charge into and out of the cell, thereby regulating neuron firing. One extremely useful technique for investigating the biophysical properties of these channels is called patch clamp recording. In this method, neuroscientists place a polished glass micropipette against a cell and apply suction to form a high resistance seal. This process isolates a small “patch” of membrane that contains one or more ion channels.
07:30
Single Cell Measurement of Dopamine Release with Simultaneous Voltage-clamp and Amperometry
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Cited by 1 •
2012
The amperometric technique measures dopamine release from a single cell by detecting the oxidative current produced by spontaneous dopamine oxidization. Simultaneous voltage clamp and amperometry methodology reveal the mechanistic relationship between the overall "activity" of dopamine transporter and the regulatory role of this activity on the reverse transport of dopamine.
05:13
Quartz-Crystal Microbalance Biosensor-Based Biopanning to Study Protein-Drug Interactions
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2025
This video demonstrates a method to study protein-drug interactions using QCM biosensor-based biopanning of the T7 phage-displayed peptide library. The biopanning of phages displaying a specific peptide on the QCM biosensor allows specific isolation of high-affinity peptides, followed by amino acid sequencing, which helps to identify specific interaction sites on the target protein.
FAQs
Controlled pressure stabilizes the quartz component without unnecessarily stressing or damaging it. The fixture applies force at defined contact points, which limits movement while preserving access to the surface being measured. Maintaining this balance is important because excessive or poorly distributed pressure could obstruct the assay surface, whereas insufficient pressure may reduce positional consistency during imaging, fluid handling, or measurement.
Defined contact points help distribute mechanical restraint in a predictable way and reduce uncontrolled movement of the quartz substrate, tube, or sensor. Their placement also matters because the clamp must secure the component without covering the surface under observation or measurement. This design supports repeatable positioning when experiments examine microbial attachment or surface-associated immune responses.
Clamping conditions influence whether the quartz component remains aligned and whether its relevant surface stays accessible. Changes in applied pressure or positioning can affect movement, obstruction, and the consistency of fluid handling or imaging. In immunology and infection studies, controlling these variables helps distinguish biological differences, such as microbial attachment or antigen-antibody interactions, from variation caused by the fixture.
Researchers first position the quartz substrate, tube, or sensor so the intended measurement surface remains available. They then align the fixture's contact points and apply controlled mechanical pressure sufficient to limit movement without obstructing the surface. Before imaging, fluid handling, or measurement, they should confirm that the component remains stable and that the clamp does not interfere with the assay.
This fixture is useful when an experiment depends on consistent positioning of a quartz-based assay component. Examples supported by the application include studies of microbial attachment, antigen-antibody interactions, and surface-associated responses. It can also support imaging or fluid-handling experiments in which movement, contamination, or accidental obstruction would make comparisons between measurements less reliable.
Consistent positioning improves repeatability by keeping the measured component in a comparable location across experimental handling and observation. Securing the quartz can also help limit movement, contamination, and damage to fragile components. These benefits are especially relevant when interpreting surface-associated measurements, because variation in fixture placement could otherwise complicate assessment of microbial attachment or immune-related interactions.