Metabolic Syndrome Model
Metabolic Syndrome Model - Related Videos
10:31
An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
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Cited by 12 •
2018
We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Cited by 69 •
2013
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
11:05
Behavioral Characterization of an Angelman Syndrome Mouse Model
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Cited by 1 •
2023
This manuscript presents a set of highly reproducible behavioral tests to validate an Angelman syndrome mouse model.
05:41
Metabolic Profile Analysis of Zebrafish Embryos
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Cited by 42 •
2013
Zebrafish represent a powerful vertebrate model that has been under-utilised for metabolic studies. Here we describe a rapid way to measure the in vivo metabolic profile of developing zebrafish that allows the comparison of different mitochondrial function parameters between genetically or pharmacologically manipulated embryos, thereby increasing the applicability of this organism.
08:31
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
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Cited by 6 •
2018
Here, we describe an optimized, Langendorff-based procedure for the isolation of single-cell atrial cardiomyocytes from a rat model of metabolic syndrome-related heart failure with preserved ejection fraction. A manual regulation of intraluminal pressure of cardiac cavities is implemented to yield functionally intact myocytes suitable for excitation-contraction-coupling studies.
FAQs
The model emphasizes coordinated disruption of glucose and lipid metabolism rather than a single abnormal measurement. Altered energy balance can link insulin resistance with abdominal obesity, dyslipidemia, and elevated blood pressure, allowing investigators to examine how these abnormalities reinforce systemic disease. This integrated view is useful for studying why metabolic dysfunction is associated with broader cardiovascular and chronic disease risk.
Defined dietary, genetic, or environmental conditions can be used to promote the metabolic abnormalities of interest. These conditions provide a controlled context for examining how disrupted energy balance affects glucose and lipid metabolism and contributes to the broader syndrome. Comparing models created under different conditions can help researchers investigate distinct routes to similar metabolic outcomes without assuming that every model reproduces disease in the same way.
A model that captures several linked abnormalities can reflect the systemic nature of metabolic syndrome more effectively than one focused only on insulin resistance. Including features such as abdominal obesity, dyslipidemia, and elevated blood pressure helps investigators study relationships among metabolic pathways and disease risk. This broader representation supports research into mechanisms that connect metabolic dysfunction with cardiovascular and related chronic conditions.
Researchers can assess whether the experimental system develops the combination of abnormalities the model is designed to reproduce, including changes in glucose and lipid metabolism, body fat distribution, and blood pressure. Interpreting these findings together is important because one abnormal result alone may not represent the interconnected syndrome. The resulting profile helps determine whether the model is suitable for mechanistic or intervention studies.
A study generally begins by selecting defined dietary, genetic, or environmental conditions, followed by evaluation of the resulting metabolic profile. Investigators then examine relevant abnormalities and their relationships, identify potential biomarkers, or test preventive and therapeutic interventions. The model’s value depends on maintaining a clear connection between the induced conditions, observed metabolic changes, and the research question being addressed.
Researchers may choose this approach when the question concerns interactions among insulin resistance, obesity, lipid abnormalities, blood pressure, and systemic disease rather than one isolated endpoint. It can support investigation of shared mechanisms, biomarkers, and interventions across several related abnormalities. In medicine, this broader context is especially relevant when studying cardiovascular risk or chronic conditions associated with metabolic dysfunction.
These models can reveal how disrupted energy balance relates to systemic metabolic disease and can provide a setting for evaluating preventive or therapeutic interventions. They also support identification of biomarkers associated with the interconnected abnormalities. Findings may help clarify whether an intervention influences a broader disease pattern involving glucose and lipid metabolism, cardiovascular risk, or related chronic conditions.