A subscription to JoVE is required to view this content. Sign in or start your free trial.
Chapters
- 00:05Title
- 00:59Acclimate Animals for 4 Weeks and Induce MetS for 28 Weeks
- 02:30Morphological Assessment
- 03:48Fasting Glycemia and Intravenous Glucose Tolerance Test
- 05:14Blood Pressure
- 06:55Plasma Measurements
- 07:57Results: Assessment of Diet-induced Metabolic Syndrome in Rabbits
- 09:48Conclusion
We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.
