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An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Article DOI: 10.3791/57117-v 10:31 min April 20th, 2018
April 20th, 2018



We describe methods to develop an experimental model of diet-induced metabolic syndrome (MetS) in rabbits using a high-fat, high-sucrose diet. Animals developed central obesity, mild hypertension, pre-diabetes, and dyslipidemia, thus reproducing the main components of human MetS. This chronic model will allow acquisition of knowledge underlying mechanisms of disease progression.


Metabolic Syndrome Model High Fat Diet High Sucrose Diet Organ Remodeling Pathophysiology Clinical Markers Therapeutic Approaches Rabbit Model Acclimation Period Control Group MetS Group Chow Intake Sucrose Solution Concentration Caloric Intake
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