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Engineering

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JoVE Journal Engineering
A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps
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A Cost-effective and Reliable Method to Predict Mechanical Stress in Single-use and Standard Pumps

Article DOI: 10.3791/53052 • 07:34 min • August 5th, 2015
August 5th, 2015 •
1, 2, 2, 3, 3, 4, 1
1Institute of Biotechnology, School of Life Sciences and Facility Management, Zurich University of Applied Sciences, 2Levitronix Ltd., 3SOPAT Ltd., 4Institute of Chemical and Process Engineering, Technische Universität Berlin

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Summary
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Shear stress investigations on an oil-water emulsion system result in drop breakup over the experimental time. To count drop sizes in pumping processes, the suitability of inline endoscopy was successfully demonstrated in this protocol.

Tags

Predict Mechanical Stress Single-use Pumps Standard Pumps Cost-effective Reliable Method Sterile Culture Broths Biopharmaceutical Production Processes Biotechnological Production Processes Shear Forces Qualitative Product Loss Quantitative Product Loss Experimental Expense Oil-water Emulsion System Drop Size Detections Bioreactors Drop Breakup Measurement Technique Liquid/liquid Dispersions Inline Endoscopy Pumping Processes Sauter Mean Diameter Representative Diameter
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