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Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung
 

Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung

Article doi: 10.3791/59450
May 20th, 2019

Summary May 20th, 2019

Intratracheal (IT) administration of experimental agents in mice often results in asymmetric delivery to the distal lungs.  In this report, we describe a direct intrabronchial (IB) approach to cannulate each lung in living mice non-operatively.  This approach can be used to selectively administer agents to one lung or may be adapted to improve the symmetric agent delivery to both lungs.

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