An in vivo physiological model of α-synuclein is required to study and understand the pathogenesis of Parkinson's disease. We describe a method to monitor the cytotoxicity and aggregate formation of α-synuclein using a humanized yeast model.
Kim, H., Jeong, J., Lee, C. A Method to Study α-Synuclein Toxicity and Aggregation Using a Humanized Yeast Model. J. Vis. Exp. (189), e64418, doi:10.3791/64418 (2022).