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Procedure for Lung Engineering
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Procedure for Lung Engineering
DOI:

12:50 min

March 08, 2011

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Chapters

  • 00:05Title
  • 01:23Bioreactor Assembly
  • 02:56Organ Decellularization
  • 05:33Organ Rinsing and Sterilization
  • 08:25Recellularization
  • 10:04Organ Culture
  • 11:14Results of Lung Engineering
  • 12:34Conclusion

Summary

Automatic Translation

We have developed a decellularized lung extracellular matrix and novel biomimetic bioreactor that can be used to generate functional lung tissue. By seeding cells into the matrix and culturing in the bioreactor, we generate tissue that demonstrates effective gas exchange when transplanted in vivo for short periods of time.

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