Alvin C. Powers Biography Publications JoVE Articles Alvin C. Powers has not added a biography. If you are Alvin C. Powers and would like to personalize this page please email our Author Liaison for assistance. Publications Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity Diabetes. Oct, 2023 | Pubmed ID: 37881846 Pancreatic Islet α Cell Function and Proliferation Requires the Arginine Transporter SLC7A2 BioRxiv : the Preprint Server for Biology. Aug, 2023 | Pubmed ID: 37645716 Understanding Cell Fate Acquisition in Stem-cell-derived Pancreatic Islets Using Single-cell Multiome-inferred Regulomes Developmental Cell. May, 2023 | Pubmed ID: 37040771 AnnoSpat Annotates Cell Types and Quantifies Cellular Arrangements from Spatial Proteomics BioRxiv : the Preprint Server for Biology. Jan, 2023 | Pubmed ID: 36712052 Images From the Exeter Archival Diabetes Biobank Now Accessible Via Pancreatlas Diabetes Care. Dec, 2022 | Pubmed ID: 36239401 Understanding Islet Dysfunction in Type 2 Diabetes Through Multidimensional Pancreatic Phenotyping: The Human Pancreas Analysis Program Cell Metabolism. Dec, 2022 | Pubmed ID: 36206763 Microvessels Enhance Vascularization and Function of Transplanted Insulin-producing Cells Cell Metabolism. Nov, 2021 | Pubmed ID: 34731653 Human Islet T Cells Are Highly Reactive to Preproinsulin in Type 1 Diabetes Proceedings of the National Academy of Sciences of the United States of America. Oct, 2021 | Pubmed ID: 34611019 Combinatorial Transcription Factor Profiles Predict Mature and Functional Human Islet α and β Cells JCI Insight. Sep, 2021 | Pubmed ID: 34428183 Debates in Pancreatic Beta Cell Biology: Proliferation Versus Progenitor Differentiation and Transdifferentiation in Restoring β Cell Mass Frontiers in Endocrinology. 2021 | Pubmed ID: 34421829 What is a β Cell? - Chapter I in the Human Islet Research Network (HIRN) Review Series Molecular Metabolism. Nov, 2021 | Pubmed ID: 34416394 Endocrine Toxicities of Immune Checkpoint Inhibitors Nature Reviews. Endocrinology. Jul, 2021 | Pubmed ID: 33875857 The Human Islet: Mini-Organ With Mega-Impact Endocrine Reviews. Sep, 2021 | Pubmed ID: 33844836 Distinguishing the Real from the Hyperglycaemia: Does COVID-19 Induce Diabetes? The Lancet. Diabetes & Endocrinology. Apr, 2021 | Pubmed ID: 33838106 Coordinated Interactions Between Endothelial Cells and Macrophages in the Islet Microenvironment Promote β Cell Regeneration NPJ Regenerative Medicine. Apr, 2021 | Pubmed ID: 33824346 Type 1 Diabetes Mellitus: Much Progress, Many Opportunities The Journal of Clinical Investigation. Apr, 2021 | Pubmed ID: 33759815 Glucagon Blockade Restores Functional β-cell Mass in Type 1 Diabetic Mice and Enhances Function of Human Islets Proceedings of the National Academy of Sciences of the United States of America. Mar, 2021 | Pubmed ID: 33619103 COVID-19 Vaccine Prioritisation for Type 1 and Type 2 Diabetes The Lancet. Diabetes & Endocrinology. Mar, 2021 | Pubmed ID: 33476583 RIPK3-mediated Inflammation is a Conserved β Cell Response to ER Stress Science Advances. Dec, 2020 | Pubmed ID: 33355143 SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells Cell Metabolism. Dec, 2020 | Pubmed ID: 33207245 Dapagliflozin Does Not Directly Affect Human α or β Cells Endocrinology. Aug, 2020 | Pubmed ID: 32428240 Decreased Pancreatic Acinar Cell Number in Type 1 Diabetes Diabetologia. Jul, 2020 | Pubmed ID: 32388592 Integrated Human Pseudoislet System and Microfluidic Platform Demonstrate Differences in GPCR Signaling in Islet Cells JCI Insight. May, 2020 | Pubmed ID: 32352931 Pancreatic Islet Beta Cell-specific Deletion of G6pc2 Reduces Fasting Blood Glucose Journal of Molecular Endocrinology. May, 2020 | Pubmed ID: 32213654 Tacrolimus- and Sirolimus-induced Human β Cell Dysfunction is Reversible and Preventable JCI Insight. Jan, 2020 | Pubmed ID: 31941840 Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice Cell Metabolism. Nov, 2019 | Pubmed ID: 31495689 Use of Human Islets to Understand Islet Biology and Diabetes: Progress, Challenges and Suggestions Diabetologia. Feb, 2019 | Pubmed ID: 30547228 β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes Diabetes. Nov, 2018 | Pubmed ID: 30150306 The Obesity Epidemic and Rising Diabetes Incidence in a Low-income Racially Diverse Southern US Cohort PloS One. 2018 | Pubmed ID: 29324894 Structural Abnormalities in Islets from Very Young Children with Cystic Fibrosis May Contribute to Cystic Fibrosis-related Diabetes Scientific Reports. Dec, 2017 | Pubmed ID: 29222447 Age-dependent Human β Cell Proliferation Induced by Glucagon-like Peptide 1 and Calcineurin Signaling The Journal of Clinical Investigation. Oct, 2017 | Pubmed ID: 28920919 Signals in the Pancreatic Islet Microenvironment Influence β-cell Proliferation Diabetes, Obesity & Metabolism. Sep, 2017 | Pubmed ID: 28880471 Rebranding Asymptomatic Type 1 Diabetes: the Case for Autoimmune Beta Cell Disorder As a Pathological and Diagnostic Entity Diabetologia. 01, 2017 | Pubmed ID: 27785529 Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas Cell Metabolism. Oct, 2016 | Pubmed ID: 27732837 G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress Endocrinology. Aug, 2016 | Pubmed ID: 27300767 Replicative Capacity of β-cells and Type 1 Diabetes Journal of Autoimmunity. Jul, 2016 | Pubmed ID: 27133598 Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function Cell Metabolism. May, 2016 | Pubmed ID: 27133132 Stress-impaired Transcription Factor Expression and Insulin Secretion in Transplanted Human Islets The Journal of Clinical Investigation. May, 2016 | Pubmed ID: 27064285 P16(Ink4a)-induced Senescence of Pancreatic Beta Cells Enhances Insulin Secretion Nature Medicine. Apr, 2016 | Pubmed ID: 26950362 The MAFB Transcription Factor Impacts Islet α-cell Function in Rodents and Represents a Unique Signature of Primate Islet β-cells American Journal of Physiology. Endocrinology and Metabolism. Jan, 2016 | Pubmed ID: 26554594 Glucagon Receptor Inactivation Leads to α-cell Hyperplasia in Zebrafish The Journal of Endocrinology. Nov, 2015 | Pubmed ID: 26446275 Suppression of Insulin Production and Secretion by a Decretin Hormone Cell Metabolism. Feb, 2015 | Pubmed ID: 25651184 β-cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment Diabetes Care. Jun, 2014 | Pubmed ID: 24812433 β-cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment The Journal of Clinical Endocrinology and Metabolism. Jun, 2014 | Pubmed ID: 24712577 Vascular Endothelial Growth Factor Coordinates Islet Innervation Via Vascular Scaffolding Development (Cambridge, England). Apr, 2014 | Pubmed ID: 24574008 The MafA Transcription Factor Becomes Essential to Islet β-cells Soon After Birth Diabetes. Jun, 2014 | Pubmed ID: 24520122 VEGF-A Recruits a Proangiogenic MMP-9-delivering Neutrophil Subset That Induces Angiogenesis in Transplanted Hypoxic Tissue Blood. Nov, 2012 | Pubmed ID: 22966168 Enhanced Expression of VEGF-A in β Cells Increases Endothelial Cell Number but Impairs Islet Morphogenesis and β Cell Proliferation Developmental Biology. Jul, 2012 | Pubmed ID: 22546694 Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice PloS One. 2012 | Pubmed ID: 22470452 マウス膵臓の β 細胞に条件付きの遺伝子をターゲット: 脳異所性 Cre 導入遺伝子発現の分析。 Diabetes. Dec, 2010 | Pubmed ID: 20802254 In Vivoでマウス膵島におけるグルコース依存性の血流ダイナミクス American Journal of Physiology. Endocrinology and Metabolism. Apr, 2010 | Pubmed ID: 20071562 四一般的に使用される近交系マウスにおけるin Vivoでのグルコース代謝 Diabetes. Jul, 2008 | Pubmed ID: 18398139 Complementation Rescue of Pdx1 Null Phenotype Demonstrates Distinct Roles of Proximal and Distal Cis-regulatory Sequences in Pancreatic and Duodenal Expression Developmental Biology. Oct, 2006 | Pubmed ID: 16962573 Reovirus Delays Diabetes Onset but Does Not Prevent Insulitis in Nonobese Diabetic Mice Journal of Virology. Mar, 2006 | Pubmed ID: 16501117 Assessment of Pancreatic Islet Mass After Islet Transplantation Using in Vivo Bioluminescence Imaging Transplantation. Apr, 2005 | Pubmed ID: 15818318 Compartmentalization of Transport and Phosphorylation of Glucose in a Hepatoma Cell Line The Biochemical Journal. Mar, 2005 | Pubmed ID: 15473866 Ascorbic Acid Recycling by Cultured Beta Cells: Effects of Increased Glucose Metabolism Free Radical Biology & Medicine. Nov, 2004 | Pubmed ID: 15477012
