In JoVE (1)
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Articles by David Z. Allen in JoVE
Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain Emily D. Geyer*1, Prithvi A. Shetty*1, Christopher J. Suozzi*1, David Z. Allen*1,2, Pamela P. Benavidez*1,2, Joseph Liu*1,3, Charles N. Hollis1, Greg A. Gerhardt4, Jorge E. Quintero4, Jason J. Burmeister4, Emmett E. Whitaker1,3 1Department of Anesthesiology, Ohio State University College of Medicine, 2Medical Student Research Program, Ohio State University College of Medicine, 3 This study explores the novel use of enzyme-based microelectrode array (MEA) technology to monitor in vivo neurotransmitter activity in piglets. The hypothesis was that glutamate dysregulation contributes to the mechanism of anesthetic neurotoxicity. Here, we present a protocol to adapt MEA technology to study the mechanism of anesthesia-induced neurotoxicity.