David R. Hinton USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics University of Southern California Biography Publications Institution JoVE Articles David R. Hinton has not added a biography. If you are David R. Hinton and would like to personalize this page please email our Author Liaison for assistance. Publications Survival of an HLA-mismatched, Bioengineered RPE Implant in Dry Age-related Macular Degeneration Stem Cell Reports. Mar, 2022 | Pubmed ID: 35120620 Mechanisms of RPE Senescence and Potential Role of αB Crystallin Peptide As a Senolytic Agent in Experimental AMD Experimental Eye Research. Feb, 2022 | Pubmed ID: 34986369 Blocking Ocular Sympathetic Activity Inhibits Choroidal Neovascularization Frontiers in Neuroscience. 2021 | Pubmed ID: 35082594 DDX17 is an Essential Mediator of Sterile NLRC4 Inflammasome Activation by Retrotransposon RNAs Science Immunology. Dec, 2021 | Pubmed ID: 34860583 Long-Term Transplant Effects of IPSC-RPE Monolayer in Immunodeficient RCS Rats Cells. 10, 2021 | Pubmed ID: 34831174 One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration Translational Vision Science & Technology. Aug, 2021 | Pubmed ID: 34613357 Complementary DNA is Enriched in Atrophic Macular Degeneration and Triggers Retinal Pigmented Epithelium Toxicity Via Cytosolic Innate Immunity Science Advances. Oct, 2021 | Pubmed ID: 34586848 Xeno-free Cryopreservation of Adherent Retinal Pigmented Epithelium Yields Viable and Functional Cells in Vitro and in Vivo Scientific Reports. 03, 2021 | Pubmed ID: 33737600 Cytoplasmic Synthesis of Endogenous Complementary DNA Via Reverse Transcription and Implications in Age-related Macular Degeneration Proceedings of the National Academy of Sciences of the United States of America. Feb, 2021 | Pubmed ID: 33526699 The Emerging Role of Senescence in Ocular Disease Oxidative Medicine and Cellular Longevity. 2020 | Pubmed ID: 32215170 Identification of Early Pericyte Loss and Vascular Amyloidosis in Alzheimer's Disease Retina Acta Neuropathologica. May, 2020 | Pubmed ID: 32043162 Surgical Method for Implantation of a Biosynthetic Retinal Pigment Epithelium Monolayer for Geographic Atrophy: Experience from a Phase 1/2a Study Ophthalmology. Retina. Mar, 2020 | Pubmed ID: 31786135 The Humanin Peptide Mediates ELP Nanoassembly and Protects Human Retinal Pigment Epithelial Cells from Oxidative Stress Nanomedicine : Nanotechnology, Biology, and Medicine. Feb, 2020 | Pubmed ID: 31655204 Sympathetic Effects of Internal Carotid Nerve Manipulation on Choroidal Vascularity and Related Measures Investigative Ophthalmology & Visual Science. Oct, 2019 | Pubmed ID: 31618767 A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration International Journal of Molecular Sciences. Sep, 2019 | Pubmed ID: 31569695 Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System Translational Vision Science & Technology. May, 2019 | Pubmed ID: 31171998 Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells Investigative Ophthalmology & Visual Science. Feb, 2019 | Pubmed ID: 30707752 APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2 Retina (Philadelphia, Pa.). Feb, 2019 | Pubmed ID: 29190236 A New Immunodeficient Retinal Dystrophic Rat Model for Transplantation Studies Using Human-derived Cells Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Nov, 2018 | Pubmed ID: 30215097 Mechanism of Cytokinesis Failure in Ovarian Cystadenomas with Defective BRCA1 and P53 Pathways International Journal of Cancer. Dec, 2018 | Pubmed ID: 29978915 Intra-vitreal αB Crystallin Fused to Elastin-like Polypeptide Provides Neuroprotection in a Mouse Model of Age-related Macular Degeneration Journal of Controlled Release : Official Journal of the Controlled Release Society. Aug, 2018 | Pubmed ID: 29778783 A Bioengineered Retinal Pigment Epithelial Monolayer for Advanced, Dry Age-related Macular Degeneration Science Translational Medicine. 04, 2018 | Pubmed ID: 29618560 CGAS Drives Noncanonical-inflammasome Activation in Age-related Macular Degeneration Nature Medicine. Jan, 2018 | Pubmed ID: 29176737 Development of a New Tissue Injector for Subretinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelium International Journal of Retina and Vitreous. 2017 | Pubmed ID: 29093829 Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models Stem Cells International. 2017 | Pubmed ID: 28928775 Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells Oxidative Medicine and Cellular Longevity. 2017 | Pubmed ID: 28814984 Retinal Amyloid Pathology and Proof-of-concept Imaging Trial in Alzheimer's Disease JCI Insight. Aug, 2017 | Pubmed ID: 28814675 Endoplasmic Reticulum-mitochondrial Crosstalk: a Novel Role for the Mitochondrial Peptide Humanin Neural Regeneration Research. Jan, 2017 | Pubmed ID: 28250736 Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes Translational Vision Science & Technology. Nov, 2016 | Pubmed ID: 27847692 Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione PloS One. 2016 | Pubmed ID: 27783653 Differential Regulation of Self-reactive CD4 T Cells in Cervical Lymph Nodes and Central Nervous System During Viral Encephalomyelitis Frontiers in Immunology. 2016 | Pubmed ID: 27708643 Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes Investigative Ophthalmology & Visual Science. 09, 2016 | Pubmed ID: 27588614 Subretinal Implantation of a Monolayer of Human Embryonic Stem Cell-derived Retinal Pigment Epithelium: a Feasibility and Safety Study in Yucatán Minipigs Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Aug, 2016 | Pubmed ID: 27335025 Survival and Functionality of HESC-Derived Retinal Pigment Epithelium Cells Cultured As a Monolayer on Polymer Substrates Transplanted in RCS Rats Investigative Ophthalmology & Visual Science. 05, 2016 | Pubmed ID: 27233037 Targeting of Exon VI-skipping Human RGR-opsin to the Plasma Membrane of Pigment Epithelium and Co-localization with Terminal Complement Complex C5b-9 Molecular Vision. 2016 | Pubmed ID: 27011730 The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction Investigative Ophthalmology & Visual Science. Mar, 2016 | Pubmed ID: 26990160 Sustained TNF Production by Central Nervous System Infiltrating Macrophages Promotes Progressive Autoimmune Encephalomyelitis Journal of Neuroinflammation. Feb, 2016 | Pubmed ID: 26906225 αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition The American Journal of Pathology. Apr, 2016 | Pubmed ID: 26878210 Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging PloS One. 2016 | Pubmed ID: 26807586 Alpha Crystallins in the Retinal Pigment Epithelium and Implications for the Pathogenesis and Treatment of Age-related Macular Degeneration Biochimica Et Biophysica Acta. Jan, 2016 | Pubmed ID: 26026469 Molecular Mechanisms of Subretinal Fibrosis in Age-related Macular Degeneration Experimental Eye Research. Jan, 2016 | Pubmed ID: 25773985 Resveratrol Inhibits Epithelial-mesenchymal Transition of Retinal Pigment Epithelium and Development of Proliferative Vitreoretinopathy Scientific Reports. Nov, 2015 | Pubmed ID: 26552368 Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy Investigative Ophthalmology & Visual Science. Aug, 2015 | Pubmed ID: 26305530 SIRT1 Mediated Inhibition of VEGF/VEGFR2 Signaling by Resveratrol and Its Relevance to Choroidal Neovascularization Cytokine. Dec, 2015 | Pubmed ID: 26174951 Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells During Coronavirus Encephalomyelitis Journal of Virology. Sep, 2015 | Pubmed ID: 26136579 Interleukin-10 is a Critical Regulator of White Matter Lesion Containment Following Viral Induced Demyelination Glia. Nov, 2015 | Pubmed ID: 26132901 Stem Cell Based Therapies for Age-related Macular Degeneration: The Promises and the Challenges Progress in Retinal and Eye Research. Sep, 2015 | Pubmed ID: 26113213 Astrocyte Response to IFN-γ Limits IL-6-mediated Microglia Activation and Progressive Autoimmune Encephalomyelitis Journal of Neuroinflammation. Apr, 2015 | Pubmed ID: 25896970 Attenuation of Choroidal Neovascularization by Histone Deacetylase Inhibitor PloS One. 2015 | Pubmed ID: 25807249 TGF-β2 Secretion from RPE Decreases with Polarization and Becomes Apically Oriented Cytokine. Feb, 2015 | Pubmed ID: 25496702 Polarized Human Embryonic Stem Cell-derived Retinal Pigment Epithelial Cell Monolayers Have Higher Resistance to Oxidative Stress-induced Cell Death Than Nonpolarized Cultures Stem Cells Translational Medicine. Jan, 2015 | Pubmed ID: 25411476 Distinct CD4 T-cell Effects on Primary Versus Recall CD8 T-cell Responses During Viral Encephalomyelitis Immunology. Mar, 2015 | Pubmed ID: 25187405 Sodium Iodate Induced Retinal Degeneration: New Insights from an Old Model Neural Regeneration Research. Dec, 2014 | Pubmed ID: 25657718 IL-18 is Not Therapeutic for Neovascular Age-related Macular Degeneration Nature Medicine. Dec, 2014 | Pubmed ID: 25473914 Nucleoside Reverse Transcriptase Inhibitors Possess Intrinsic Anti-inflammatory Activity Science (New York, N.Y.). Nov, 2014 | Pubmed ID: 25414314 Pharmacological Protection of Retinal Pigmented Epithelial Cells by Sulindac Involves PPAR-α Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25385631 DICER1/Alu RNA Dysmetabolism Induces Caspase-8-mediated Cell Death in Age-related Macular Degeneration Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25349431 IL-27 Limits Central Nervous System Viral Clearance by Promoting IL-10 and Enhances Demyelination Journal of Immunology (Baltimore, Md. : 1950). Jul, 2014 | Pubmed ID: 24890725 Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration PloS One. 2014 | Pubmed ID: 24874187 Protein Polymer Nanoparticles Engineered As Chaperones Protect Against Apoptosis in Human Retinal Pigment Epithelial Cells Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2014 | Pubmed ID: 24780268 Ceramide Inhibits Connective Tissue Growth Factor Expression by Human Retinal Pigment Epithelial Cells Cytokine. Aug, 2014 | Pubmed ID: 24758915 PKR Mediated Regulation of Inflammation and IL-10 During Viral Encephalomyelitis Journal of Neuroimmunology. May, 2014 | Pubmed ID: 24642385 Ifit2 Deficiency Results in Uncontrolled Neurotropic Coronavirus Replication and Enhanced Encephalitis Via Impaired Alpha/beta Interferon Induction in Macrophages Journal of Virology. Jan, 2014 | Pubmed ID: 24198415 Role of CD25(+) CD4(+) T Cells in Acute and Persistent Coronavirus Infection of the Central Nervous System Virology. Dec, 2013 | Pubmed ID: 24210105 MMP-independent Role of TIMP-1 at the Blood Brain Barrier During Viral Encephalomyelitis ASN Neuro. Nov, 2013 | Pubmed ID: 24156369 TLR-independent and P2X7-dependent Signaling Mediate Alu RNA-induced NLRP3 Inflammasome Activation in Geographic Atrophy Investigative Ophthalmology & Visual Science. Nov, 2013 | Pubmed ID: 24114535 IL-21 Optimizes T Cell and Humoral Responses in the Central Nervous System During Viral Encephalitis Journal of Neuroimmunology. Oct, 2013 | Pubmed ID: 23992866 Subretinal Implantation of Retinal Pigment Epithelial Cells Derived from Human Embryonic Stem Cells: Improved Survival when Implanted As a Monolayer Investigative Ophthalmology & Visual Science. Jul, 2013 | Pubmed ID: 23833067 Antiapoptotic Properties of α-crystallin-derived Peptide Chaperones and Characterization of Their Uptake Transporters in Human RPE Cells Investigative Ophthalmology & Visual Science. Apr, 2013 | Pubmed ID: 23532520 Astrocyte-derived CXCL10 Drives Accumulation of Antibody-secreting Cells in the Central Nervous System During Viral Encephalomyelitis Journal of Virology. Mar, 2013 | Pubmed ID: 23302888 GRP78 Plays an Essential Role in Adipogenesis and Postnatal Growth in Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2013 | Pubmed ID: 23180827 Enhanced CD8 T-cell Anti-viral Function and Clinical Disease in B7-H1-deficient Mice Requires CD4 T Cells During Encephalomyelitis Journal of Neuroinflammation. Dec, 2012 | Pubmed ID: 23237504 Angiofibrotic Response to Vascular Endothelial Growth Factor Inhibition in Diabetic Retinal Detachment: Report No. 1 Archives of Ophthalmology (Chicago, Ill. : 1960). Sep, 2012 | Pubmed ID: 22965588 Green Tea Polyphenols Precondition Against Cell Death Induced by Oxygen-glucose Deprivation Via Stimulation of Laminin Receptor, Generation of Reactive Oxygen Species, and Activation of Protein Kinase Cε The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22879598 ERK1/2 Activation is a Therapeutic Target in Age-related Macular Degeneration Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22869729 A Novel Approach for Subretinal Implantation of Ultrathin Substrates Containing Stem Cell-derived Retinal Pigment Epithelium Monolayer Ophthalmic Research. 2012 | Pubmed ID: 22868580 IFN-γ Signaling to Astrocytes Protects from Autoimmune Mediated Neurological Disability PloS One. 2012 | Pubmed ID: 22848713 Deficiency of αB Crystallin Augments ER Stress-induced Apoptosis by Enhancing Mitochondrial Dysfunction Free Radical Biology & Medicine. Sep, 2012 | Pubmed ID: 22781655 Novel Roles for α-crystallins in Retinal Function and Disease Progress in Retinal and Eye Research. Nov, 2012 | Pubmed ID: 22721717 IFN-γ Protects from Lethal IL-17 Mediated Viral Encephalomyelitis Independent of Neutrophils Journal of Neuroinflammation. May, 2012 | Pubmed ID: 22642802 DICER1 Loss and Alu RNA Induce Age-related Macular Degeneration Via the NLRP3 Inflammasome and MyD88 Cell. May, 2012 | Pubmed ID: 22541070 Mechanism of RPE Cell Death in α-crystallin Deficient Mice: a Novel and Critical Role for MRP1-mediated GSH Efflux PloS One. 2012 | Pubmed ID: 22442691 Over-expression of BMP4 Inhibits Experimental Choroidal Neovascularization by Modulating VEGF and MMP-9 Angiogenesis. Jun, 2012 | Pubmed ID: 22392094 CD4 T Cells Promote CD8 T Cell Immunity at the Priming and Effector Site During Viral Encephalitis Journal of Virology. Mar, 2012 | Pubmed ID: 22205741 WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing Cancer Cell. Dec, 2011 | Pubmed ID: 22172722 VEGF and PEDF Secretion in ARPE-19 and FhRPE Cells Investigative Ophthalmology & Visual Science. Nov, 2011 | Pubmed ID: 22104197 Methionine Sulfoxide Reductase A: Structure, Function and Role in Ocular Pathology World Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21909460 Regulation of Fibronectin-EDA Through CTGF Domain-specific Interactions with TGFβ2 and Its Receptor TGFβRII Investigative Ophthalmology & Visual Science. Jul, 2011 | Pubmed ID: 21571675 Shifting Hierarchies of Interleukin-10-producing T Cell Populations in the Central Nervous System During Acute and Persistent Viral Encephalomyelitis Journal of Virology. Jul, 2011 | Pubmed ID: 21525347 CXCR3-dependent Plasma Blast Migration to the Central Nervous System During Viral Encephalomyelitis Journal of Virology. Jul, 2011 | Pubmed ID: 21507985 Transcriptional Regulation of Bone Morphogenetic Protein 4 by Tumor Necrosis Factor and Its Relationship with Age-related Macular Degeneration FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2011 | Pubmed ID: 21411747 Antenatal Maternal Stress Alters Functional Brain Responses in Adult Offspring During Conditioned Fear Brain Research. Apr, 2011 | Pubmed ID: 21300034 DICER1 Deficit Induces Alu RNA Toxicity in Age-related Macular Degeneration Nature. Mar, 2011 | Pubmed ID: 21297615 Sonoporation Enhances Chemotherapeutic Efficacy in Retinoblastoma Cells in Vitro Investigative Ophthalmology & Visual Science. May, 2011 | Pubmed ID: 21273549 Transport of Hepcidin, an Iron-regulatory Peptide Hormone, into Retinal Pigment Epithelial Cells Via Oligopeptide Transporters and Its Relevance to Iron Homeostasis Biochemical and Biophysical Research Communications. Feb, 2011 | Pubmed ID: 21219868 Factors Supporting Intrathecal Humoral Responses Following Viral Encephalomyelitis Journal of Virology. Mar, 2011 | Pubmed ID: 21191015 Polarized Secretion of PEDF from Human Embryonic Stem Cell-derived RPE Promotes Retinal Progenitor Cell Survival Investigative Ophthalmology & Visual Science. Mar, 2011 | Pubmed ID: 21087957 Vitreal Oxygenation in Retinal Ischemia Reperfusion Investigative Ophthalmology & Visual Science. Feb, 2011 | Pubmed ID: 21051734 Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-induced Acute Pancreatitis The American Journal of Pathology. Dec, 2010 | Pubmed ID: 20971738 αB Crystallin is Apically Secreted Within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells PloS One. Oct, 2010 | Pubmed ID: 20949024 Green Tea Polyphenols Potentiate the Action of Nerve Growth Factor to Induce Neuritogenesis: Possible Role of Reactive Oxygen Species Journal of Neuroscience Research. Dec, 2010 | Pubmed ID: 20936703 Enhanced Antiviral T Cell Function in the Absence of B7-H1 is Insufficient to Prevent Persistence but Exacerbates Axonal Bystander Damage During Viral Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20876353 Recombinant Human VEGF165b Inhibits Experimental Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Aug, 2010 | Pubmed ID: 20237252 Neutrophils Compromise Retinal Pigment Epithelial Barrier Integrity Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20204129 Gamma Interferon Signaling in Oligodendrocytes is Critical for Protection from Neurotropic Coronavirus Infection Journal of Virology. Mar, 2010 | Pubmed ID: 20042510 AlphaB-crystallin Regulation of Angiogenesis by Modulation of VEGF Blood. Apr, 2010 | Pubmed ID: 20023214 Essential Role of the Unfolded Protein Response Regulator GRP78/BiP in Protection from Neuronal Apoptosis Cell Death and Differentiation. Mar, 2010 | Pubmed ID: 19816510 Expression and Regulation of Enzymes in the Ceramide Metabolic Pathway in Human Retinal Pigment Epithelial Cells and Their Relevance to Retinal Degeneration Vision Research. Mar, 2010 | Pubmed ID: 19765607 Soluble EphB4 Inhibition of PDGF-induced RPE Migration in Vitro Investigative Ophthalmology & Visual Science. Jan, 2010 | Pubmed ID: 19696168 Identification of a Novel Sodium-coupled Oligopeptide Transporter (SOPT2) in Mouse and Human Retinal Pigment Epithelial Cells Investigative Ophthalmology & Visual Science. Jan, 2010 | Pubmed ID: 19643969 Attainment of Polarity Promotes Growth Factor Secretion by Retinal Pigment Epithelial Cells: Relevance to Age-related Macular Degeneration Aging. Dec, 2009 | Pubmed ID: 20228934 What Determines the Switch Between Atrophic and Neovascular Forms of Age Related Macular Degeneration? - the Role of BMP4 Induced Senescence Aging. Aug, 2009 | Pubmed ID: 20157553 RNase L Mediated Protection from Virus Induced Demyelination PLoS Pathogens. Oct, 2009 | Pubmed ID: 19798426 A Protocol for the Culture and Differentiation of Highly Polarized Human Retinal Pigment Epithelial Cells Nature Protocols. 2009 | Pubmed ID: 19373231 Regulated Secretion of Complement Factor H by RPE and Its Role in RPE Migration Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. May, 2009 | Pubmed ID: 19214553 BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and is Overexpressed in Age-related Macular Degeneration The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19158083 Immunocytochemical Analysis of Retinal Neurons Under Electrical Stimulation Brain Research. Feb, 2009 | Pubmed ID: 19103179 Regulation of Thioredoxin by Ceramide in Retinal Pigment Epithelial Cells Experimental Eye Research. Mar, 2009 | Pubmed ID: 18996115 Memory CD4+ T-cell-mediated Protection from Lethal Coronavirus Encephalomyelitis Journal of Virology. Dec, 2008 | Pubmed ID: 18842712 Toll-like Receptor 3 and Geographic Atrophy in Age-related Macular Degeneration The New England Journal of Medicine. Oct, 2008 | Pubmed ID: 18753640 The Immune Response to Herpes Simplex Virus Type 1 Infection in Susceptible Mice is a Major Cause of Central Nervous System Pathology Resulting in Fatal Encephalitis Journal of Virology. Jul, 2008 | Pubmed ID: 18480436 Connective Tissue Growth Factor As a Mediator of Intraocular Fibrosis Investigative Ophthalmology & Visual Science. Sep, 2008 | Pubmed ID: 18450591 N-(4-hydroxyphenyl) Retinamide Augments Laser-induced Choroidal Neovascularization in Mice Investigative Ophthalmology & Visual Science. Mar, 2008 | Pubmed ID: 18326751 Endoplasmic Reticulum Stress Induced by Oxidative Stress in Retinal Pigment Epithelial Cells Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. May, 2008 | Pubmed ID: 18278507 Exacerbation of Retinal Degeneration in the Absence of Alpha Crystallins in an in Vivo Model of Chemically Induced Hypoxia Experimental Eye Research. Feb, 2008 | Pubmed ID: 18191123 CD4 T Cells Contribute to Virus Control and Pathology Following Central Nervous System Infection with Neurotropic Mouse Hepatitis Virus Journal of Virology. Mar, 2008 | Pubmed ID: 18094171 Type I Interferons Are Essential in Controlling Neurotropic Coronavirus Infection Irrespective of Functional CD8 T Cells Journal of Virology. Jan, 2008 | Pubmed ID: 17928334 Alpha-Crystallin Distribution in Retinal Pigment Epithelium and Effect of Gene Knockouts on Sensitivity to Oxidative Stress Molecular Vision. Apr, 2007 | Pubmed ID: 17438522 In Vivo Models of Proliferative Vitreoretinopathy Nature Protocols. 2007 | Pubmed ID: 17401340 Population-based Study of Early Age-related Macular Degeneration: Role of the Complement Factor H Y402H Polymorphism in Bilateral but Not Unilateral Disease Ophthalmology. Jan, 2007 | Pubmed ID: 17198853 Thrombospondin-1 Expression in RPE and Choroidal Neovascular Membranes Yan Ke Xue Bao = Eye Science. Dec, 2006 | Pubmed ID: 17378161 Stimulation of Apical and Basolateral VEGF-A and VEGF-C Secretion by Oxidative Stress in Polarized Retinal Pigment Epithelial Cells Molecular Vision. Dec, 2006 | Pubmed ID: 17200665 Liver X Receptor Activation Decreases the Severity of Experimental Autoimmune Encephalomyelitis Journal of Neuroscience Research. Nov, 2006 | Pubmed ID: 16955483 Altered Neuroantigen-specific Cytokine Secretion in a Th2 Environment Reduces Experimental Autoimmune Encephalomyelitis Journal of Neuroimmunology. Sep, 2006 | Pubmed ID: 16814872 Thiol Regulation of Vascular Endothelial Growth Factor-A and Its Receptors in Human Retinal Pigment Epithelial Cells Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16793007 Expression of Protein Kinase CK2 in Astroglial Cells of Normal and Neovascularized Retina The American Journal of Pathology. May, 2006 | Pubmed ID: 16651637 MMP-2 and MMP-9 Secretion by Rpe is Stimulated by Angiogenic Molecules Found in Choroidal Neovascular Membranes Retina (Philadelphia, Pa.). Apr, 2006 | Pubmed ID: 16603966 Transforming Growth Factor Beta2-induced Myofibroblastic Differentiation of Human Retinal Pigment Epithelial Cells: Regulation by Extracellular Matrix Proteins and Hepatocyte Growth Factor Experimental Eye Research. Jul, 2006 | Pubmed ID: 16563380 Mouse Hepatitis Virus Pathogenesis in the Central Nervous System is Independent of IL-15 and Natural Killer Cells Virology. Jun, 2006 | Pubmed ID: 16510164 Inhibition of Interferon-gamma Signaling in Oligodendroglia Delays Coronavirus Clearance Without Altering Demyelination The American Journal of Pathology. Mar, 2006 | Pubmed ID: 16507895 CNS Viral Infection Diverts Homing of Antibody-secreting Cells from Lymphoid Organs to the CNS European Journal of Immunology. Mar, 2006 | Pubmed ID: 16437540 Characterization of Brimonidine Transport in Retinal Pigment Epithelium Investigative Ophthalmology & Visual Science. Jan, 2006 | Pubmed ID: 16384975 Sequential Induction of Angiogenic Growth Factors by TNF-alpha in Choroidal Endothelial Cells Journal of Neuroimmunology. Feb, 2006 | Pubmed ID: 16288810 Neuropilin-1 Expression by Endothelial Cells and Retinal Pigment Epithelial Cells in Choroidal Neovascular Membranes American Journal of Ophthalmology. Dec, 2005 | Pubmed ID: 16376649 Soluble EphB4 Regulates Choroidal Endothelial Cell Function and Inhibits Laser-induced Choroidal Neovascularization Investigative Ophthalmology & Visual Science. Dec, 2005 | Pubmed ID: 16303978 In Vivo Expression of GFP Transgene Delivered Via a Replicating Feline Leukemia Virus Veterinary Microbiology. Oct, 2005 | Pubmed ID: 16143471 Astrocyte Expression of a Dominant-negative Interferon-gamma Receptor Journal of Neuroscience Research. Oct, 2005 | Pubmed ID: 16118798 Protection from Oxidative Stress by Methionine Sulfoxide Reductases in RPE Cells Biochemical and Biophysical Research Communications. Aug, 2005 | Pubmed ID: 15993845 Neutrophils Promote Experimental Choroidal Neovascularization Molecular Vision. Jun, 2005 | Pubmed ID: 15988410 A Selective Cyclic Integrin Antagonist Blocks the Integrin Receptors Alphavbeta3 and Alphavbeta5 and Inhibits Retinal Pigment Epithelium Cell Attachment, Migration and Invasion BMC Ophthalmology. Jun, 2005 | Pubmed ID: 15987521 Differential Expression of Pro- and Antiangiogenic Factors in Mouse Strain-dependent Hypoxia-induced Retinal Neovascularization Laboratory Investigation; a Journal of Technical Methods and Pathology. Jun, 2005 | Pubmed ID: 15856049 Maintenance of CD8+ T Cells During Acute Viral Infection of the Central Nervous System Requires CD4+ T Cells but Not Interleukin-2 Viral Immunology. 2005 | Pubmed ID: 15802960 Expression of Matrix Metalloproteinases and Their Tissue Inhibitor During Viral Encephalitis Journal of Virology. Apr, 2005 | Pubmed ID: 15795262 Expression of a Dominant Negative IFN-gammareceptor on Mouse Oligodendrocytes Glia. Jul, 2005 | Pubmed ID: 15779088 Differential Regulation of Primary and Secondary CD8+ T Cells in the Central Nervous System Journal of Immunology (Baltimore, Md. : 1950). Nov, 2004 | Pubmed ID: 15528365 Ceramide-induced Apoptosis: Role of Catalase and Hepatocyte Growth Factor Free Radical Biology & Medicine. Jul, 2004 | Pubmed ID: 15203188 Gene Therapy in a Murine Model for Clinical Application to Multiple Sclerosis Annals of Neurology. Mar, 2004 | Pubmed ID: 14991817 Accumulation of NH2-terminal Fragment of Connective Tissue Growth Factor in the Vitreous of Patients with Proliferative Diabetic Retinopathy Diabetes Care. Mar, 2004 | Pubmed ID: 14988298 Perforin and Gamma Interferon-mediated Control of Coronavirus Central Nervous System Infection by CD8 T Cells in the Absence of CD4 T Cells Journal of Virology. Feb, 2004 | Pubmed ID: 14747539 Mouse Strain-dependent Heterogeneity of Resting Limbal Vasculature Investigative Ophthalmology & Visual Science. Feb, 2004 | Pubmed ID: 14744883 Hepatocyte Growth Factor and Its Role in the Pathogenesis of Retinal Detachment Investigative Ophthalmology & Visual Science. Jan, 2004 | Pubmed ID: 14691191 Developmental Retinal Apoptosis in Ku86-/- Mice DNA Repair. Dec, 2003 | Pubmed ID: 14642570 A Role for Connective Tissue Growth Factor in the Pathogenesis of Choroidal Neovascularization Archives of Ophthalmology (Chicago, Ill. : 1960). Sep, 2003 | Pubmed ID: 12963611 Neutrophils Promote Mononuclear Cell Infiltration During Viral-induced Encephalitis Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003 | Pubmed ID: 12626593 The Art of Survival During Viral Persistence Journal of Neurovirology. Dec, 2002 | Pubmed ID: 12491152 Regulation of RPE Intercellular Junction Integrity and Function by Hepatocyte Growth Factor Investigative Ophthalmology & Visual Science. Aug, 2002 | Pubmed ID: 12147616 Matrix Metalloproteinase Expression Correlates with Virulence Following Neurotropic Mouse Hepatitis Virus Infection Journal of Virology. Aug, 2002 | Pubmed ID: 12097550 Oxygen Metabolism Causes Chromosome Breaks and is Associated with the Neuronal Apoptosis Observed in DNA Double-strand Break Repair Mutants Current Biology : CB. Mar, 2002 | Pubmed ID: 11882291 Viral Induced Demyelination Brain Pathology (Zurich, Switzerland). Jan, 2001 | Pubmed ID: 11145206 Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells Sarcoma. 2000 | Pubmed ID: 18521433 Contributions of Fas-Fas Ligand Interactions to the Pathogenesis of Mouse Hepatitis Virus in the Central Nervous System Journal of Virology. Mar, 2000 | Pubmed ID: 10666278 Transgenic Interleukin 10 Prevents Induction of Experimental Autoimmune Encephalomyelitis The Journal of Experimental Medicine. Mar, 1999 | Pubmed ID: 10075984 Expression of Hemagglutinin/esterase by a Mouse Hepatitis Virus Coronavirus Defective-interfering RNA Alters Viral Pathogenesis Virology. Mar, 1998 | Pubmed ID: 9501044 Expression of Interferon-gamma by a Coronavirus Defective-interfering RNA Vector and Its Effect on Viral Replication, Spread, and Pathogenicity Virology. Jul, 1997 | Pubmed ID: 9217056 Kinetics of Cytokine MRNA Expression in the Central Nervous System Following Lethal and Nonlethal Coronavirus-induced Acute Encephalomyelitis Virology. Jul, 1997 | Pubmed ID: 9217050 Development of a Surgical Technique for Subretinal Implants in Rats Juan Carlos Martinez Camarillo1,2, Yuntao Hu1,5, Biju B. Thomas1,2, Danhong Zhu3, David R. Hinton2,3, Debbie Mitra1,2, Jose Miguel Mora Correa2, Deepthi S. Rajendran Nair1,2, Jane Lebkowski4, Mark S. Humayun1,2 1USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, 2USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, 3Department of Pathology, Keck School of Medicine of the University of Southern California, 4Regenerative Patch Technologies LLC, 5Eye center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University JoVE 64585 Medicine
Development of a Surgical Technique for Subretinal Implants in Rats Juan Carlos Martinez Camarillo1,2, Yuntao Hu1,5, Biju B. Thomas1,2, Danhong Zhu3, David R. Hinton2,3, Debbie Mitra1,2, Jose Miguel Mora Correa2, Deepthi S. Rajendran Nair1,2, Jane Lebkowski4, Mark S. Humayun1,2 1USC Roski Eye Institute, Keck School of Medicine of the University of Southern California, 2USC Dr. Allen and Charlotte Ginsburg Institute for Biomedical Therapeutics, University of Southern California, 3Department of Pathology, Keck School of Medicine of the University of Southern California, 4Regenerative Patch Technologies LLC, 5Eye center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University JoVE 64585 Medicine