Joseph P. Noel Biography Publications JoVE Articles Joseph P. Noel has not added a biography. If you are Joseph P. Noel and would like to personalize this page please email our Author Liaison for assistance. Publications Plant-based CO Drawdown and Storage As SiC RSC Advances. Apr, 2021 | Pubmed ID: 35481209 Interfacial Plasticity Facilitates High Reaction Rate of FAS Malonyl-CoA:ACP Transacylase, FabD Proceedings of the National Academy of Sciences of the United States of America. 09, 2020 | Pubmed ID: 32929027 Activity Mapping the Acyl Carrier Protein: Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis Biochemistry. 09, 2020 | Pubmed ID: 32857494 Algal Neurotoxin Biosynthesis Repurposes the Terpene Cyclase Structural Fold into an -prenyltransferase Proceedings of the National Academy of Sciences of the United States of America. 06, 2020 | Pubmed ID: 32457155 Modulation of Auxin Formation by the Cytosolic Phenylalanine Biosynthetic Pathway Nature Chemical Biology. 08, 2020 | Pubmed ID: 32284603 Gating Mechanism of Elongating β-ketoacyl-ACP Synthases Nature Communications. 04, 2020 | Pubmed ID: 32265440 Dissecting Modular Synthases Through Inhibition: A Complementary Chemical and Genetic Approach Bioorganic & Medicinal Chemistry Letters. 01, 2020 | Pubmed ID: 31812466 Strigolactone Perception and Deactivation by a Hydrolase Receptor DWARF14 Nature Communications. 01, 2019 | Pubmed ID: 30643123 Contribution of Isopentenyl Phosphate to Plant Terpenoid Metabolism Nature Plants. 09, 2018 | Pubmed ID: 30127411 Publisher Correction: Evolution of Chalcone Isomerase from a Noncatalytic Ancestor Nature Chemical Biology. Oct, 2018 | Pubmed ID: 29760514 Evolution of Chalcone Isomerase from a Noncatalytic Ancestor Nature Chemical Biology. 06, 2018 | Pubmed ID: 29686356 A Coupled in Vitro/in Vivo Approach for Engineering a Heterologous Type III PKS to Enhance Polyketide Biosynthesis in Saccharomyces Cerevisiae Biotechnology and Bioengineering. 06, 2018 | Pubmed ID: 29457628 Molecular Architectures of Benzoic Acid-specific Type III Polyketide Synthases Acta Crystallographica. Section D, Structural Biology. Dec, 2017 | Pubmed ID: 29199980 A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis Journal of the American Chemical Society. 11, 2017 | Pubmed ID: 29083151 Structural Basis for Specific Ligation of the Peroxisome Proliferator-activated Receptor δ Proceedings of the National Academy of Sciences of the United States of America. 03, 2017 | Pubmed ID: 28320959 Corrigendum to "Unveiling the Functional Diversity of the Alpha/beta Hydrolase Superfamily in the Plant Kingdom" [Curr Opin Struct Biol 2016, 41:233-246] Current Opinion in Structural Biology. 12, 2016 | Pubmed ID: 27884574 Dynamic Conformational States Dictate Selectivity Toward the Native Substrate in a Substrate-Permissive Acyltransferase Biochemistry. 11, 2016 | Pubmed ID: 27805809 Unveiling the Functional Diversity of the Alpha/beta Hydrolase Superfamily in the Plant Kingdom Current Opinion in Structural Biology. 12, 2016 | Pubmed ID: 27662376 Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity Cell. Aug, 2016 | Pubmed ID: 27518563 Biosynthetic Potential of Sesquiterpene Synthases: Product Profiles of Egyptian Henbane Premnaspirodiene Synthase and Related Mutants The Journal of Antibiotics. 07, 2016 | Pubmed ID: 27328867 Local Auxin Metabolism Regulates Environment-induced Hypocotyl Elongation Nature Plants. 03, 2016 | Pubmed ID: 27249562 Biosynthesis of Coral Settlement Cue Tetrabromopyrrole in Marine Bacteria by a Uniquely Adapted Brominase-thioesterase Enzyme Pair Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27001835 Harvesting the Biosynthetic Machineries That Cultivate a Variety of Indispensable Plant Natural Products Current Opinion in Chemical Biology. 04, 2016 | Pubmed ID: 26851514 Cryptochrome 1 Interacts with PIF4 to Regulate High Temperature-mediated Hypocotyl Elongation in Response to Blue Light Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016 | Pubmed ID: 26699514 Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases ACS Chemical Biology. Nov, 2015 | Pubmed ID: 26378620 Orthologs of the Archaeal Isopentenyl Phosphate Kinase Regulate Terpenoid Production in Plants Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015 | Pubmed ID: 26216978 Structural Studies of Cinnamoyl-CoA Reductase and Cinnamyl-alcohol Dehydrogenase, Key Enzymes of Monolignol Biosynthesis The Plant Cell. Sep, 2014 | Pubmed ID: 25217505 Spectral and Structural Comparison Between Bright and Dim Green Fluorescent Proteins in Amphioxus Scientific Reports. Jun, 2014 | Pubmed ID: 24968921 Genetically Encoding Photoswitchable Click Amino Acids in Escherichia Coli and Mammalian Cells Angewandte Chemie (International Ed. in English). Apr, 2014 | Pubmed ID: 24615769 The Phosphopantetheinyl Transferases: Catalysis of a Post-translational Modification Crucial for Life Natural Product Reports. Jan, 2014 | Pubmed ID: 24292120 Genetic Basis for the Biosynthesis of the Pharmaceutically Important Class of Epoxyketone Proteasome Inhibitors ACS Chemical Biology. Jan, 2014 | Pubmed ID: 24168704 Discovery of a Metabolic Alternative to the Classical Mevalonate Pathway ELife. Dec, 2013 | Pubmed ID: 24327557 Flavin-mediated Dual Oxidation Controls an Enzymatic Favorskii-type Rearrangement Nature. Nov, 2013 | Pubmed ID: 24162851 Expanding the Library and Substrate Diversity of the Pyrrolysyl-tRNA Synthetase to Incorporate Unnatural Amino Acids Containing Conjugated Rings Chembiochem : a European Journal of Chemical Biology. Nov, 2013 | Pubmed ID: 24019075 Chemodiversity in Selaginella: a Reference System for Parallel and Convergent Metabolic Evolution in Terrestrial Plants Frontiers in Plant Science. 2013 | Pubmed ID: 23717312 Smoke-derived Karrikin Perception by the α/β-hydrolase KAI2 from Arabidopsis Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23613584 Confluence of Structural and Chemical Biology: Plant Polyketide Synthases As Biocatalysts for a Bio-based Future Current Opinion in Plant Biology. Jun, 2013 | Pubmed ID: 23481348 Coordination of Auxin and Ethylene Biosynthesis by the Aminotransferase VAS1 Nature Chemical Biology. Apr, 2013 | Pubmed ID: 23377040 Identification of a 3-aminoimidazo[1,2-a]pyridine Inhibitor of HIV-1 Reverse Transcriptase Virology Journal. 2012 | Pubmed ID: 23231773 Structure-function Analyses of Plant Type III Polyketide Synthases Methods in Enzymology. 2012 | Pubmed ID: 22999180 Architectures, Mechanisms and Molecular Evolution of Natural Product Methyltransferases Natural Product Reports. Oct, 2012 | Pubmed ID: 22850796 The Rise of Chemodiversity in Plants Science (New York, N.Y.). Jun, 2012 | Pubmed ID: 22745420 Evolution of the Chalcone-isomerase Fold from Fatty-acid Binding to Stereospecific Catalysis Nature. May, 2012 | Pubmed ID: 22622584 Emergent Decarboxylase Activity and Attenuation of α/β-hydrolase Activity During the Evolution of Methylketone Biosynthesis in Tomato The Plant Cell. Apr, 2012 | Pubmed ID: 22523203 Genetically Encoding Unnatural Amino Acids in Neural Stem Cells and Optically Reporting Voltage-sensitive Domain Changes in Differentiated Neurons Stem Cells (Dayton, Ohio). Aug, 2011 | Pubmed ID: 21681861 Structural Basis of Steroid Hormone Perception by the Receptor Kinase BRI1 Nature. Jun, 2011 | Pubmed ID: 21666665 Stereochemical Basis for Engineered Pyrrolysyl-tRNA Synthetase and the Efficient in Vivo Incorporation of Structurally Divergent Non-native Amino Acids ACS Chemical Biology. Jul, 2011 | Pubmed ID: 21545173 Structure-function Analyses of a Caffeic Acid O-methyltransferase from Perennial Ryegrass Reveal the Molecular Basis for Substrate Preference The Plant Cell. Dec, 2010 | Pubmed ID: 21177481 Functional Analyses of Caffeic Acid O-Methyltransferase and Cinnamoyl-CoA-reductase Genes from Perennial Ryegrass (Lolium Perenne) The Plant Cell. Oct, 2010 | Pubmed ID: 20952635 Enzymatic Functions of Wild Tomato Methylketone Synthases 1 and 2 Plant Physiology. Sep, 2010 | Pubmed ID: 20605911 Mutation of Archaeal Isopentenyl Phosphate Kinase Highlights Mechanism and Guides Phosphorylation of Additional Isoprenoid Monophosphates ACS Chemical Biology. Jun, 2010 | Pubmed ID: 20392112 Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-fluorofarnesyl Diphosphates ACS Chemical Biology. Apr, 2010 | Pubmed ID: 20175559 Multiple Biochemical and Morphological Factors Underlie the Production of Methylketones in Tomato Trichomes Plant Physiology. Dec, 2009 | Pubmed ID: 19801397 The Lack of Floral Synthesis and Emission of Isoeugenol in Petunia Axillaris Subsp. Parodii is Due to a Mutation in the Isoeugenol Synthase Gene The Plant Journal : for Cell and Molecular Biology. Jun, 2009 | Pubmed ID: 19222805 Biosynthesis of T-anethole in Anise: Characterization of T-anol/isoeugenol Synthase and an O-methyltransferase Specific for a C7-C8 Propenyl Side Chain Plant Physiology. Jan, 2009 | Pubmed ID: 18987218 Quantitative Exploration of the Catalytic Landscape Separating Divergent Plant Sesquiterpene Synthases Nature Chemical Biology. Oct, 2008 | Pubmed ID: 18776889 S-Adenosyl-L-methionine Hydrolase (adenosine-forming), a Conserved Bacterial and Archaeal Protein Related to SAM-dependent Halogenases Chembiochem : a European Journal of Chemical Biology. Sep, 2008 | Pubmed ID: 18720493 Chemoenzymatic Syntheses of Prenylated Aromatic Small Molecules Using Streptomyces Prenyltransferases with Relaxed Substrate Specificities Bioorganic & Medicinal Chemistry. Sep, 2008 | Pubmed ID: 18682327 Rapid Synthesis of Auxin Via a New Tryptophan-dependent Pathway is Required for Shade Avoidance in Plants Cell. Apr, 2008 | Pubmed ID: 18394996 Metabolite Induction of Caenorhabditis Elegans Dauer Larvae Arises Via Transport in the Pharynx ACS Chemical Biology. May, 2008 | Pubmed ID: 18376812 Evolving Biosynthetic Tangos Negotiate Mechanistic Landscapes Nature Chemical Biology. Apr, 2008 | Pubmed ID: 18347585 The Multiple Phenylpropene Synthases in Both Clarkia Breweri and Petunia Hybrida Represent Two Distinct Protein Lineages The Plant Journal : for Cell and Molecular Biology. May, 2008 | Pubmed ID: 18208524 Structural, Biochemical, and Phylogenetic Analyses Suggest That Indole-3-acetic Acid Methyltransferase is an Evolutionarily Ancient Member of the SABATH Family Plant Physiology. Feb, 2008 | Pubmed ID: 18162595 Discovery and Characterization of a Marine Bacterial SAM-dependent Chlorinase Nature Chemical Biology. Jan, 2008 | Pubmed ID: 18059261 Digging for Answers, Smelling a Hint of Success and Tasting Triumph Nature Chemical Biology. Nov, 2007 | Pubmed ID: 17948014 Structure and Reaction Mechanism of Basil Eugenol Synthase PloS One. Oct, 2007 | Pubmed ID: 17912370 Interception of the Enzymatic Conversion of Farnesyl Diphosphate to 5-epi-aristolochene by Using a Fluoro Substrate Analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl Diphosphate Chembiochem : a European Journal of Chemical Biology. Oct, 2007 | Pubmed ID: 17886322 Functional Characterization of Premnaspirodiene Oxygenase, a Cytochrome P450 Catalyzing Regio- and Stereo-specific Hydroxylations of Diverse Sesquiterpene Substrates The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17715131 Genetisch Codierung Unnatürlichen Aminosäuren Für Zell-und Neuronale Nature Neuroscience. Aug, 2007 | Pubmed ID: 17603477 A Soluble, Magnesium-independent Prenyltransferase Catalyzes Reverse and Regular C-prenylations and O-prenylations of Aromatic Substrates FEBS Letters. Jun, 2007 | Pubmed ID: 17543953 Structural Basis for High-affinity Peptide Inhibition of Human Pin1 ACS Chemical Biology. May, 2007 | Pubmed ID: 17518432 Discovery of Two Cyanobacterial Phenylalanine Ammonia Lyases: Kinetic and Structural Characterization Biochemistry. Jan, 2007 | Pubmed ID: 17240984 Methylation of Gibberellins by Arabidopsis GAMT1 and GAMT2 The Plant Cell. Jan, 2007 | Pubmed ID: 17220201 Metabolic Engineering of Sesquiterpene Metabolism in Yeast Biotechnology and Bioengineering. May, 2007 | Pubmed ID: 17013941 Structural Determinants and Modulation of Substrate Specificity in Phenylalanine-tyrosine Ammonia-lyases Chemistry & Biology. Dec, 2006 | Pubmed ID: 17185228 Structural Basis for the Modulation of CDK-dependent/independent Activity of Cyclin D1 Cell Cycle (Georgetown, Tex.). Dec, 2006 | Pubmed ID: 17172845 Structural Basis for Dual Functionality of Isoflavonoid O-methyltransferases in the Evolution of Plant Defense Responses The Plant Cell. Dec, 2006 | Pubmed ID: 17172354 Determinanten Für Die Dephosphorylierung Von Der RNS-Polymerase II C-terminalen Domäne Von Scp1 Molecular Cell. Dec, 2006 | Pubmed ID: 17157258 Type III Polyketide Synthase Beta-ketoacyl-ACP Starter Unit and Ethylmalonyl-CoA Extender Unit Selectivity Discovered by Streptomyces Coelicolor Genome Mining Journal of the American Chemical Society. Nov, 2006 | Pubmed ID: 17105255 Functional Analysis of Members of the Isoflavone and Isoflavanone O-methyltransferase Enzyme Families from the Model Legume Medicago Truncatula Plant Molecular Biology. Nov, 2006 | Pubmed ID: 17001495 Biosynthesis of Dictyostelium Discoideum Differentiation-inducing Factor by a Hybrid Type I Fatty Acid-type III Polyketide Synthase Nature Chemical Biology. Sep, 2006 | Pubmed ID: 16906151 Structural Basis for the Design of Potent and Species-specific Inhibitors of 3-hydroxy-3-methylglutaryl CoA Synthases Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16864776 Structure-function-folding Relationship in a WW Domain Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16807295 Identifying and Manipulating Structural Determinates Linking Catalytic Specificities in Terpene Synthases Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16785438 Eugenol and Isoeugenol, Characteristic Aromatic Constituents of Spices, Are Biosynthesized Via Reduction of a Coniferyl Alcohol Ester Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16782809 Methylation of Sulfhydryl Groups: a New Function for a Family of Small Molecule Plant O-methyltransferases The Plant Journal : for Cell and Molecular Biology. Apr, 2006 | Pubmed ID: 16623883 Absence of Substrate Channeling Between Active Sites in the Agrobacterium Tumefaciens IspDF and IspE Enzymes of the Methyl Erythritol Phosphate Pathway Biochemistry. Mar, 2006 | Pubmed ID: 16533036 Biosynthesis of Plant Volatiles: Nature's Diversity and Ingenuity Science (New York, N.Y.). Feb, 2006 | Pubmed ID: 16469917 Biosynthetic Potential of Sesquiterpene Synthases: Alternative Products of Tobacco 5-epi-aristolochene Synthase Archives of Biochemistry and Biophysics. Apr, 2006 | Pubmed ID: 16375847 Stereochemistry and Deuterium Isotope Effects Associated with the Cyclization-rearrangements Catalyzed by Tobacco Epiaristolochene and Hyoscyamus Premnaspirodiene Synthases, and the Chimeric CH4 Hybrid Cyclase Archives of Biochemistry and Biophysics. Apr, 2006 | Pubmed ID: 16309622 An Arabidopsis Thaliana Methyltransferase Capable of Methylating Farnesoic Acid Archives of Biochemistry and Biophysics. Apr, 2006 | Pubmed ID: 16165084 Structural Elucidation of Chalcone Reductase and Implications for Deoxychalcone Biosynthesis The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15970585 Structural Basis for the Promiscuous Biosynthetic Prenylation of Aromatic Natural Products Nature. Jun, 2005 | Pubmed ID: 15959519 Floral Benzenoid Carboxyl Methyltransferases: from in Vitro to in Planta Function Phytochemistry. Jun, 2005 | Pubmed ID: 15946712 Structure of the Mg-chelatase Cofactor GUN4 Reveals a Novel Hand-shaped Fold for Porphyrin Binding PLoS Biology. May, 2005 | Pubmed ID: 15884974 Structure-function Relationships in Plant Phenylpropanoid Biosynthesis Current Opinion in Plant Biology. Jun, 2005 | Pubmed ID: 15860421 Structural and Kinetic Basis for Substrate Selectivity in Populus Tremuloides Sinapyl Alcohol Dehydrogenase The Plant Cell. May, 2005 | Pubmed ID: 15829607 Crystal Structures of Alfalfa Caffeoyl Coenzyme A 3-O-methyltransferase Plant Physiology. Mar, 2005 | Pubmed ID: 15734921 Kinetic and Molecular Analysis of 5-epiaristolochene 1,3-dihydroxylase, a Cytochrome P450 Enzyme Catalyzing Successive Hydroxylations of Sesquiterpenes The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15522862 A Single-vial Analytical and Quantitative Gas Chromatography-mass Spectrometry Assay for Terpene Synthases Analytical Biochemistry. Dec, 2004 | Pubmed ID: 15556559 An Aldol Switch Discovered in Stilbene Synthases Mediates Cyclization Specificity of Type III Polyketide Synthases Chemistry & Biology. Sep, 2004 | Pubmed ID: 15380179 Kinetic Analysis of Escherichia Coli 2-C-methyl-D-erythritol-4-phosphate Cytidyltransferase, Wild Type and Mutants, Reveals Roles of Active Site Amino Acids Biochemistry. Sep, 2004 | Pubmed ID: 15379557 Biochemical and Structural Characterization of Benzenoid Carboxyl Methyltransferases Involved in Floral Scent Production in Stephanotis Floribunda and Nicotiana Suaveolens Plant Physiology. Aug, 2004 | Pubmed ID: 15310828 Crystal Structure of a Bacterial Type III Polyketide Synthase and Enzymatic Control of Reactive Polyketide Intermediates The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15265863 Structural Basis for Substrate Recognition in the Salicylic Acid Carboxyl Methyltransferase Family The Plant Cell. Aug, 2003 | Pubmed ID: 12897246 The Structure of the Membrane Distal Phosphatase Domain of RPTPalpha Reveals Interdomain Flexibility and an SH2 Domain Interaction Region Biochemistry. Jul, 2003 | Pubmed ID: 12834342 A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR Molecular Cell. Apr, 2003 | Pubmed ID: 12718892 The Chalcone Synthase Superfamily of Type III Polyketide Synthases Natural Product Reports. Feb, 2003 | Pubmed ID: 12636085 Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT Domain E3 Ligase Molecular Cell. Jan, 2003 | Pubmed ID: 12535537 Structural Basis for the Modulation of Lignin Monomer Methylation by Caffeic Acid/5-hydroxyferulic Acid 3/5-O-methyltransferase The Plant Cell. Jun, 2002 | Pubmed ID: 12084826 Expanding the Biosynthetic Repertoire of Plant Type III Polyketide Synthases by Altering Starter Molecule Specificity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11959984 Role of Hydrogen Bonds in the Reaction Mechanism of Chalcone Isomerase Biochemistry. Apr, 2002 | Pubmed ID: 11955065 Characterization of Phenylpropene O-methyltransferases from Sweet Basil: Facile Change of Substrate Specificity and Convergent Evolution Within a Plant O-methyltransferase Family The Plant Cell. Feb, 2002 | Pubmed ID: 11884690 Structure and Mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate Synthase. An Enzyme in the Mevalonate-independent Isoprenoid Biosynthetic Pathway The Journal of Biological Chemistry. Mar, 2002 | Pubmed ID: 11786530 Reaction Mechanism of Chalcone Isomerase. PH Dependence, Diffusion Control, and Product Binding Differences The Journal of Biological Chemistry. Jan, 2002 | Pubmed ID: 11698411
