María I. Loza Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS) Universidad de Santiago de Compostela Biography Publications Institution JoVE Articles María I. Loza has not added a biography. If you are María I. Loza and would like to personalize this page please email our Author Liaison for assistance. Publications Essential Role of the C148-C227 Disulphide Bridge in the Human 5-HT Homodimeric Receptor Biochemical Pharmacology. Jul, 2020 | Pubmed ID: 32311347 A Novel NMDA Receptor Antagonist Protects Against Cognitive Decline Presented by Senescent Mice Pharmaceutics. Mar, 2020 | Pubmed ID: 32235699 A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade Thrombosis and Haemostasis. Feb, 2020 | Pubmed ID: 31901221 Pharmacology and Preclinical Validation of a Novel Anticancer Compound Targeting PEPCK-M Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. Jan, 2020 | Pubmed ID: 31739159 Fibrates As Drugs with Senolytic and Autophagic Activity for Osteoarthritis Therapy EBioMedicine. Jul, 2019 | Pubmed ID: 31285188 5-HT2 Receptor Binding, Functional Activity and Selectivity in N-benzyltryptamines PloS One. 2019 | Pubmed ID: 30629611 Genetic Enhancement of Ras-ERK Pathway Does Not Aggravate L-DOPA-induced Dyskinesia in Mice but Prevents the Decrease Induced by Lovastatin Scientific Reports. 10, 2018 | Pubmed ID: 30337665 Fingerprint-Based Machine Learning Approach to Identify Potent and Selective 5-HTR Ligands Molecules (Basel, Switzerland). 05, 2018 | Pubmed ID: 29748476 Serotonin 2A Receptor Disulfide Bridge Integrity is Crucial for Ligand Binding to Different Signalling States but Not for Its Homodimerization European Journal of Pharmacology. Nov, 2017 | Pubmed ID: 28899696 Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects Molecules (Basel, Switzerland). Sep, 2017 | Pubmed ID: 28869560 Serotonin-2A Homodimers Are Needed for Signalling Via Both Phospholipase A and Phospholipase C in Transfected CHO Cells European Journal of Pharmacology. Apr, 2017 | Pubmed ID: 28216047 Synthesis and Biological Evaluation of a Series of Aminoalkyl-tetralones and Tetralols As Dual Dopamine/serotonin Ligands European Journal of Medicinal Chemistry. Jan, 2014 | Pubmed ID: 24316025 Synthesis and Binding Affinity of New 1,4-disubstituted Triazoles As Potential Dopamine D(3) Receptor Ligands Bioorganic & Medicinal Chemistry Letters. Oct, 2013 | Pubmed ID: 24012118 Synthesis and Binding Affinity of Potential Atypical Antipsychotics with the Tetrahydroquinazolinone Motif Bioorganic & Medicinal Chemistry Letters. Nov, 2009 | Pubmed ID: 19796944 Synthesis, Binding Affinity and SAR of New Benzolactam Derivatives As Dopamine D3 Receptor Ligands Bioorganic & Medicinal Chemistry Letters. Mar, 2009 | Pubmed ID: 19217777 Synthesis, Binding Affinity, and Molecular Docking Analysis of New Benzofuranone Derivatives As Potential Antipsychotics Journal of Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18783204 Synthesis and Binding Affinity of New Pyrazole and Isoxazole Derivatives As Potential Atypical Antipsychotics Bioorganic & Medicinal Chemistry Letters. Sep, 2007 | Pubmed ID: 17588750 Synthesis and Binding Affinity of Novel 3-aminoethyl-1-tetralones, Potential Atypical Antipsychotics Bioorganic & Medicinal Chemistry Letters. Jun, 2005 | Pubmed ID: 15878662 Chemoenzymatic Synthesis and Binding Affinity of Novel (R)- and (S)-3-aminomethyl-1-tetralones, Potential Atypical Antipsychotics Bioorganic & Medicinal Chemistry Letters. Feb, 2004 | Pubmed ID: 14741248 Flux-Based Assay for the Identification of Autophagy Modulators for Osteoarthritis Uxía Nogueira-Recalde1, Irene Lorenzo-Gómez1, María I. Loza2, Eduardo Domínguez2, Beatriz Caramés1 1Grupo de Biología del Cartílago, Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña, 2Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela JoVE 61078 Biology
Flux-Based Assay for the Identification of Autophagy Modulators for Osteoarthritis Uxía Nogueira-Recalde1, Irene Lorenzo-Gómez1, María I. Loza2, Eduardo Domínguez2, Beatriz Caramés1 1Grupo de Biología del Cartílago, Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña, 2Biofarma Research Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidad de Santiago de Compostela JoVE 61078 Biology