In JoVE (1)
Other Publications (1)
Articles by Marie C. P. Roland in JoVE
The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo Ane M. Holme1,2, Maia B. Holm1,2, Marie C. P. Roland1,3, Hildegunn Horne1,2, Trond M. Michelsen1,3, Guttorm Haugen2,4, Tore Henriksen1,2 1Department of Obstetrics, Oslo University Hospital, 2Institute of Clinical Medicine, University of Oslo, 3Norwegian Advisory Unit on Women's Health, Oslo University Hospital, 4Department of Fetal Medicine, Oslo University Hospital We present a detailed method to study human placental physiology in vivo at term. The method combines blood sampling from the incoming and outgoing vessels on the maternal and fetal sides of the placenta with ultrasound measurements of volume blood flow and placental tissue sampling.
Other articles by Marie C. P. Roland on PubMed
In vivo Uteroplacental Release of Placental Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Normal and Preeclamptic Pregnancies American Journal of Obstetrics and Gynecology. Dec, 2016 | Pubmed ID: 27503620 Preeclampsia is characterized by maternal endothelial dysfunction, which underlies a highly diverse clinical presentation. The pathophysiologic condition remains to be unraveled fully, but interplay between factors that are released from the placenta and maternal vascular vulnerability is likely. An imbalance in circulating angiogenic factors is a prominent feature of preeclampsia; placental growth factor and soluble Fms-like tyrosine kinase 1 have been implemented as biomarkers of placental function and preeclampsia. Their test accuracies are limited in a clinical setting, which urges better insight into their production and removal. Current data suggest that placental growth factor and soluble Fms-like tyrosine kinase 1 are released from the placenta. Both the circulating levels and the placental expression are altered in preeclamptic pregnancies. However, in vivo placental release has not been determined in human pregnancies. Moreover, there is evidence that extra-placental tissues might contribute to the circulating levels placental growth factor and soluble Fms-like tyrosine kinase 1 in normal and preeclamptic pregnancies.