Mia M. Thi Department of Orthopaedic Surgery Albert Einstein College of Medicine Biography Publications Institution JoVE Articles Mia M. Thi has not added a biography. If you are Mia M. Thi and would like to personalize this page please email our Author Liaison for assistance. Publications Estrogen Depletion on In Vivo Osteocyte Calcium Signaling Responses to Mechanical Loading Bone. Nov, 2021 | Pubmed ID: 34171514 Generation and Characterization of Immortalized Mouse Cortical Astrocytes From Wildtype and Connexin43 Knockout Mice Frontiers in Cellular Neuroscience. 2021 | Pubmed ID: 33790744 Mechanosensitive Vaginal Epithelial Adenosine Triphosphate Release and Pannexin 1 Channels in Healthy, in Type 1 Diabetic, and in Surgically Castrated Female Mice The Journal of Sexual Medicine. May, 2020 | Pubmed ID: 32241676 CITED2 Mediates the Cross-talk Between Mechanical Loading and IL-4 to Promote Chondroprotection Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30891766 Role of Pannexin 1 Channels in Load-induced Skeletal Response Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 29952014 Potential Role for a Specialized β Integrin-based Structure on Osteocyte Processes in Bone Mechanosensation Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Feb, 2018 | Pubmed ID: 29087614 Osteocyte Calcium Signals Encode Strain Magnitude and Loading Frequency in Vivo Proceedings of the National Academy of Sciences of the United States of America. Oct, 2017 | Pubmed ID: 29078317 A New Perspective on Mechanisms Governing Skeletal Complications in Type 1 Diabetes Annals of the New York Academy of Sciences. Nov, 2016 | Pubmed ID: 27571221 P2X7R-Panx1 Complex Impairs Bone Mechanosignaling Under High Glucose Levels Associated with Type-1 Diabetes PloS One. 2016 | Pubmed ID: 27159053 Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Apr, 2016 | Pubmed ID: 26553756 Loss of Hepatic Chaperone-mediated Autophagy Accelerates Proteostasis Failure in Aging Aging Cell. Apr, 2015 | Pubmed ID: 25620427 Pannexin 1 Channels Play Essential Roles in Urothelial Mechanotransduction and Intercellular Signaling PloS One. 2014 | Pubmed ID: 25170954 Adipocytes in Both Brown and White Adipose Tissue of Adult Mice Are Functionally Connected Via Gap Junctions: Implications for Chagas Disease Microbes and Infection. Nov, 2014 | Pubmed ID: 25150689 Mechanosensory Responses of Osteocytes to Physiological Forces Occur Along Processes and Not Cell Body and Require αVβ3 Integrin Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013 | Pubmed ID: 24324138 Age-related Carbonylation of Fibrocartilage Structural Proteins Drives Tissue Degenerative Modification Chemistry & Biology. Jul, 2013 | Pubmed ID: 23890010 Gap Junctions and Bystander Effects: Good Samaritans and Executioners Wiley Interdisciplinary Reviews. Membrane Transport and Signaling. Jan, 2013 | Pubmed ID: 23565352 Connexin43 and Pannexin1 Channels in Osteoblasts: Who is the "hemichannel"? The Journal of Membrane Biology. Jul, 2012 | Pubmed ID: 22797941 An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes) Cellular and Molecular Bioengineering. Dec, 2011 | Pubmed ID: 23976901 Characterization of HTERT-immortalized Osteoblast Cell Lines Generated from Wild-type and Connexin43-null Mouse Calvaria American Journal of Physiology. Cell Physiology. Nov, 2010 | Pubmed ID: 20686067 Fluid Flow-induced Soluble Vascular Endothelial Growth Factor Isoforms Regulate Actin Adaptation in Osteoblasts The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20682775 IGF-I Regulates Tight-junction Protein Claudin-1 During Differentiation of Osteoblast-like MC3T3-E1 Cells Via a MAP-kinase Pathway Cell and Tissue Research. Nov, 2008 | Pubmed ID: 18855015 Aquaporin-4 Water Channels in Enteric Neurons Journal of Neuroscience Research. Feb, 2008 | Pubmed ID: 17893913 Fluid Shear Stress Upregulates Vascular Endothelial Growth Factor Gene Expression in Osteoblasts Annals of the New York Academy of Sciences. Nov, 2007 | Pubmed ID: 17646268 The Role of the Glycocalyx in Reorganization of the Actin Cytoskeleton Under Fluid Shear Stress: a "bumper-car" Model Proceedings of the National Academy of Sciences of the United States of America. Nov, 2004 | Pubmed ID: 15545600 A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes Karl J. Lewis1, James F. Boorman-Padgett3, Macy Castaneda2, David C. Spray4, Mia M. Thi5,6, Mitchell B. Schaffler3 1Meinig School of Biomedical Engineering, Cornell University, 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, 3Department of Biomedical Engineering, The City College of New York, 4Department of Neuroscience, Albert Einstein College of Medicine, 5Department of Orthopaedic Surgery, Albert Einstein College of Medicine, 6Department of Molecular Pharmacology, Albert Einstein College of Medicine JoVE 64366 Bioengineering
A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes Karl J. Lewis1, James F. Boorman-Padgett3, Macy Castaneda2, David C. Spray4, Mia M. Thi5,6, Mitchell B. Schaffler3 1Meinig School of Biomedical Engineering, Cornell University, 2Sibley School of Mechanical and Aerospace Engineering, Cornell University, 3Department of Biomedical Engineering, The City College of New York, 4Department of Neuroscience, Albert Einstein College of Medicine, 5Department of Orthopaedic Surgery, Albert Einstein College of Medicine, 6Department of Molecular Pharmacology, Albert Einstein College of Medicine JoVE 64366 Bioengineering