Michael W. Epperly Department of Radiation Oncology University of Pittsburgh Cancer Institute Biography Publications Institution JoVE Articles Michael W. Epperly has not added a biography. If you are Michael W. Epperly and would like to personalize this page please email our Author Liaison for assistance. Publications Allogeneic Adipose-derived Stem Cells Mitigate Acute Radiation Syndrome by the Rescue of Damaged Bone Marrow Cells from Apoptosis Stem Cells Translational Medicine. 07, 2021 | Pubmed ID: 33724714 Adipose-Derived Stem Cell Therapy Ameliorates Ionizing Irradiation Fibrosis Via Hepatocyte Growth Factor-Mediated Transforming Growth Factor-β Downregulation and Recruitment of Bone Marrow Cells Stem Cells (Dayton, Ohio). 06, 2019 | Pubmed ID: 30861238 Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor ACS Chemical Biology. 10, 2018 | Pubmed ID: 30184433 Development of Tensile Strength Methodology for Murine Skin Wound Healing MethodsX. 2018 | Pubmed ID: 30050753 Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca and Fancg Mice by Intraoral Administration of GS-Nitroxide (JP4-039) Radiation Research. 06, 2018 | Pubmed ID: 29584588 Liquid Chromatography-tandem Mass Spectrometric Assay for the Quantitation of the Novel Radiation Protective Agent and Radiation Mitigator JP4-039 in Murine Plasma Journal of Pharmaceutical and Biomedical Analysis. Feb, 2018 | Pubmed ID: 29245086 Reduced Competitive Repopulation Capacity of Multipotential Hematopoietic Stem Cells in the Bone Marrow of Friend Virus-infected Fv2-resistant Mice In Vivo (Athens, Greece). May-Jun, 2017 | Pubmed ID: 28438857 Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350 In Vivo (Athens, Greece). Mar-Apr, 2017 | Pubmed ID: 28358695 Effectiveness of Analogs of the GS-Nitroxide, JP4-039, As Total Body Irradiation Mitigators In Vivo (Athens, Greece). 01, 2017 | Pubmed ID: 28064218 Evolution of Malignant Plasmacytoma Cell Lines from K14E7 Fancd2-/- Mouse Long-term Bone Marrow Cultures Oncotarget. 10, 2016 | Pubmed ID: 27637088 Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice Radiation Research. Feb, 2016 | Pubmed ID: 26789701 Radioresistant Human Lung Adenocarcinoma Cells That Survived Multiple Fractions of Ionizing Radiation Are Sensitive to HSP90 Inhibition Oncotarget. Dec, 2015 | Pubmed ID: 26517240 The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells Cancers. May, 2015 | Pubmed ID: 26010604 Pulmonary Receptor for Advanced Glycation End-products Promotes Asthma Pathogenesis Through IL-33 and Accumulation of Group 2 Innate Lymphoid Cells The Journal of Allergy and Clinical Immunology. Sep, 2015 | Pubmed ID: 25930197 Organ-specific Responses of Total Body Irradiated Doxycycline-inducible Manganese Superoxide Dismutase Tet/Tet Mice In Vivo (Athens, Greece). Nov-Dec, 2014 | Pubmed ID: 25398796 Improved Hematopoiesis in GS-nitroxide (JP4-039)-treated Mouse Long-term Bone Marrow Cultures and Radioresistance of Derived Bone Marrow Stromal Cell Lines In Vivo (Athens, Greece). Sep-Oct, 2014 | Pubmed ID: 25189880 Effects of the Bifunctional Sulfoxide MMS350, a Radiation Mitigator, on Hematopoiesis in Long-term Bone Marrow Cultures and on Radioresistance of Marrow Stromal Cell Lines In Vivo (Athens, Greece). Jul-Aug, 2014 | Pubmed ID: 24982210 Increased Hematopoiesis in Long-term Bone Marrow Cultures and Reduced Irradiation-induced Pulmonary Fibrosis in Von Willebrand Factor Homologous Deletion Recombinant Mice In Vivo (Athens, Greece). Jul-Aug, 2014 | Pubmed ID: 24982209 Improved Longevity of Hematopoiesis in Long-term Bone Marrow Cultures and Reduced Irradiation-induced Pulmonary Fibrosis in Toll-like Receptor-4 Deletion Recombinant-negative Mice In Vivo (Athens, Greece). Jul-Aug, 2014 | Pubmed ID: 24982208 Amelioration of Radiation-Induced Oral Cavity Mucositis and Distant Bone Marrow Suppression in Fanconi Anemia Fancd2(-/-) (FVB/N) Mice by Intraoral GS-Nitroxide JP4-039 Radiation Research. Jul, 2014 | Pubmed ID: 24932534 Differences in Irradiated Lung Gene Transcription Between Fibrosis-prone C57BL/6NHsd and Fibrosis-resistant C3H/HeNHsd Mice In Vivo (Athens, Greece). Mar-Apr, 2014 | Pubmed ID: 24632969 Can Radiosensitivity Associated with Defects in DNA Repair Be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors Frontiers in Oncology. 2014 | Pubmed ID: 24596683 Improved Survival of Mice After Total Body Irradiation with 10 MV Photon, 2400 MU/min SRS Beam In Vivo (Athens, Greece). Jan-Feb, 2014 | Pubmed ID: 24425830 Radiologic Differences Between Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines from Fanconi Anemia (Fancd2(-/-)) Mice Radiation Research. Jan, 2014 | Pubmed ID: 24397476 Amelioration of Radiation-induced Pulmonary Fibrosis by a Water-soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350) Radiation Research. Nov, 2013 | Pubmed ID: 24125487 Radioresistance of Bone Marrow Stromal and Hematopoietic Progenitor Cell Lines Derived from Nrf2-/- Homozygous Deletion Recombinant-negative Mice In Vivo (Athens, Greece). Sep-Oct, 2013 | Pubmed ID: 23988890 Evaluation of Potential Ionizing Irradiation Protectors and Mitigators Using Clonogenic Survival of Human Umbilical Cord Blood Hematopoietic Progenitor Cells Experimental Hematology. Nov, 2013 | Pubmed ID: 23933481 Conditional Radioresistance of Tet-inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines Radiation Research. Aug, 2013 | Pubmed ID: 23862693 Synthesis of Analogs of the Radiation Mitigator JP4-039 and Visualization of BODIPY Derivatives in Mitochondria Organic & Biomolecular Chemistry. Jul, 2013 | Pubmed ID: 23715589 Effects of Thoracic Irradiation on Pulmonary Endothelial Compared to Alveolar Type-II Cells in Fibrosis-prone C57BL/6NTac Mice In Vivo (Athens, Greece). May-Jun, 2013 | Pubmed ID: 23606683 The Zebrafish--Danio Rerio--is a Useful Model for Measuring the Effects of Small-molecule Mitigators of Late Effects of Ionizing Irradiation In Vivo (Athens, Greece). Nov-Dec, 2012 | Pubmed ID: 23160669 Dysregulated in Vitro Hematopoiesis, Radiosensitivity, Proliferation, and Osteoblastogenesis with Marrow from SAMP6 Mice Experimental Hematology. Jun, 2012 | Pubmed ID: 22326715 Repopulation of the Irradiation Damaged Lung with Bone Marrow-derived Cells In Vivo (Athens, Greece). Jan-Feb, 2012 | Pubmed ID: 22210711 Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators Frontiers in Oncology. 2011 | Pubmed ID: 22655254 Role of the Esophageal Vagus Neural Pathway in Ionizing Irradiation-induced Seizures in Nitric Oxide Synthase-1 Homologous Recombinant Negative NOS1-/- Mice In Vivo (Athens, Greece). Nov-Dec, 2011 | Pubmed ID: 22021678 Amelioration of Radiation Esophagitis by Orally Administered P53/Mdm2/Mdm4 Inhibitor (BEB55) or GS-nitroxide In Vivo (Athens, Greece). Nov-Dec, 2011 | Pubmed ID: 22021675 GS-nitroxide (JP4-039)-mediated Radioprotection of Human Fanconi Anemia Cell Lines Radiation Research. Nov, 2011 | Pubmed ID: 21939290 The Use of 3,5,4'-Tri-O-acetylresveratrol As a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death ACS Medicinal Chemistry Letters. Jan, 2011 | Pubmed ID: 21826253 The Autophagy-inducing Drug Carbamazepine is a Radiation Protector and Mitigator International Journal of Radiation Biology. Oct, 2011 | Pubmed ID: 21728759 Radiobiologic Effects of GS-nitroxide (JP4-039) on the Hematopoietic Syndrome In Vivo (Athens, Greece). May-Jun, 2011 | Pubmed ID: 21576404 Two Strategies for the Development of Mitochondrion-targeted Small Molecule Radiation Damage Mitigators International Journal of Radiation Oncology, Biology, Physics. Jul, 2011 | Pubmed ID: 21493014 Antioxidant-chemoprevention Diet Ameliorates Late Effects of Total-body Irradiation and Supplements Radioprotection by MnSOD-plasmid Liposome Administration Radiation Research. Jun, 2011 | Pubmed ID: 21466381 Modulation of in Utero Total Body Irradiation Induced Newborn Mouse Growth Retardation by Maternal Manganese Superoxide Dismutase-plasmid Liposome (MnSOD-PL) Gene Therapy Gene Therapy. Jun, 2011 | Pubmed ID: 21248791 A Phase I Study of Concurrent Chemotherapy (paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-small-cell Lung Cancer Human Gene Therapy. Mar, 2011 | Pubmed ID: 20873987 Intraesophageal Administration of GS-nitroxide (JP4-039) Protects Against Ionizing Irradiation-induced Esophagitis In Vivo (Athens, Greece). Nov-Dec, 2010 | Pubmed ID: 21164038 Effects of Irradiating Adult Mdx Mice Before Full-length Dystrophin CDNA Transfer on Host Anti-dystrophin Immunity Gene Therapy. Sep, 2010 | Pubmed ID: 20827278 Intraesophageal Manganese Superoxide Dismutase-plasmid Liposomes Ameliorates Novel Total-body and Thoracic Radiation Sensitivity of NOS1-/- Mice Radiation Research. Sep, 2010 | Pubmed ID: 20726721 Small Molecule GS-nitroxide Ameliorates Ionizing Irradiation-induced Delay in Bone Wound Healing in a Novel Murine Model In Vivo (Athens, Greece). Jul-Aug, 2010 | Pubmed ID: 20668303 Screening of Antimicrobial Agents for in Vitro Radiation Protection and Mitigation Capacity, Including Those Used in Supportive Care Regimens for Bone Marrow Transplant Recipients In Vivo (Athens, Greece). Jan-Feb, 2010 | Pubmed ID: 20133970 Effectiveness of Combined Modality Radiotherapy of Orthotopic Human Squamous Cell Carcinomas in Nu/Nu Mice Using Cetuximab, Tirapazamine and MnSOD-plasmid Liposome Gene Therapy In Vivo (Athens, Greece). Jan-Feb, 2010 | Pubmed ID: 20133969 The Mitochondria-targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair In Vivo (Athens, Greece). Sep-Oct, 2009 | Pubmed ID: 19779106 Investigation of the Effects of Aging on Homologous Recombination in Long-term Bone Marrow Cultures In Vivo (Athens, Greece). Sep-Oct, 2009 | Pubmed ID: 19779099 Mitochondrial Targeting of a Catalase Transgene Product by Plasmid Liposomes Increases Radioresistance in Vitro and in Vivo Radiation Research. May, 2009 | Pubmed ID: 19580494 Modulation of Radiation-induced Life Shortening by Systemic Intravenous MnSOD-plasmid Liposome Gene Therapy Radiation Research. Oct, 2008 | Pubmed ID: 19024650 Regulation of the Anaphase-promoting Complex-separase Cascade by Transforming Growth Factor-beta Modulates Mitotic Progression in Bone Marrow Stromal Cells Molecular Biology of the Cell. Dec, 2008 | Pubmed ID: 18843049 Radioprotection in Vitro and in Vivo by Minicircle Plasmid Carrying the Human Manganese Superoxide Dismutase Transgene Human Gene Therapy. Aug, 2008 | Pubmed ID: 18699723 Overexpression of the MnSOD Transgene Product Protects Cryopreserved Bone Marrow Hematopoietic Progenitor Cells from Ionizing Radiation Radiation Research. Nov, 2007 | Pubmed ID: 17973554 Review. Antioxidant Gene Therapeutic Approaches to Normal Tissue Radioprotection and Tumor Radiosensitization In Vivo (Athens, Greece). Mar-Apr, 2007 | Pubmed ID: 17436562 Effects of MnSOD-plasmid Liposome Gene Therapy on Antioxidant Levels in Irradiated Murine Oral Cavity Orthotopic Tumors Radiation Research. Mar, 2007 | Pubmed ID: 17316075 Increased Longevity of Hematopoiesis in Continuous Bone Marrow Cultures Derived from NOS1 (nNOS, MtNOS) Homozygous Recombinant Negative Mice Correlates with Radioresistance of Hematopoietic and Marrow Stromal Cells Experimental Hematology. Jan, 2007 | Pubmed ID: 17198882 Effect of EGFR Antagonists Gefitinib (Iressa) and C225 (Cetuximab) on MnSOD-plasmid Liposome Transgene Radiosensitization of a Murine Squamous Cell Carcinoma Cell Line In Vivo (Athens, Greece). Nov-Dec, 2006 | Pubmed ID: 17203769 Reduced Irradiation Pulmonary Fibrosis and Stromal Cell Migration in Smad3-/- Marrow Chimeric Mice In Vivo (Athens, Greece). Sep-Oct, 2006 | Pubmed ID: 17091762 Bone Marrow from CD18-/- (MAC-1-/-) Homozygous Deletion Recombinant Negative Mice Demonstrates Increased Longevity in Long-term Bone Marrow Culture and Decreased Contribution to Irradiation Pulmonary Damage In Vivo (Athens, Greece). Jul-Aug, 2006 | Pubmed ID: 16900771 Increased Radioresistance, G(2)/m Checkpoint Inhibition, and Impaired Migration of Bone Marrow Stromal Cell Lines Derived from Smad3(-/-) Mice Radiation Research. Jun, 2006 | Pubmed ID: 16802867 Thalidomide Radiosensitization of Normal Murine Hematopoietic but Not Squamous Cell Carcinoma or Multiple Myeloma Tumor Cell Lines In Vivo (Athens, Greece). May-Jun, 2006 | Pubmed ID: 16724666 MnSOD-plasmid Liposome Gene Therapy Decreases Ionizing Irradiation-induced Lipid Peroxidation of the Esophagus In Vivo (Athens, Greece). Nov-Dec, 2005 | Pubmed ID: 16277013 Increased Longevity of Hematopoiesis in Continuous Bone Marrow Cultures and Adipocytogenesis in Marrow Stromal Cells Derived from Smad3(-/-) Mice Experimental Hematology. Mar, 2005 | Pubmed ID: 15730859 In Vitro Differentiation Capacity of Esophageal Progenitor Cells with Capacity for Homing and Repopulation of the Ionizing Irradiation-damaged Esophagus In Vivo (Athens, Greece). Nov-Dec, 2004 | Pubmed ID: 15646807 Abrogation of Head and Neck Squamous Cell Carcinoma Growth by Epidermal Growth Factor Receptor Ligand Fused to Pseudomonas Exotoxin Transforming Growth Factor Alpha-PE38 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15501988 Intraoral Manganese Superoxide Dismutase-plasmid/liposome (MnSOD-PL) Radioprotective Gene Therapy Decreases Ionizing Irradiation-induced Murine Mucosal Cell Cycling and Apoptosis In Vivo (Athens, Greece). Jul-Aug, 2004 | Pubmed ID: 15369176 Bone Marrow Origin of Cells with Capacity for Homing and Differentiation to Esophageal Squamous Epithelium Radiation Research. Sep, 2004 | Pubmed ID: 15333000 Correlation of Ionizing Irradiation-induced Late Pulmonary Fibrosis with Long-term Bone Marrow Culture Fibroblast Progenitor Cell Biology in Mice Homozygous Deletion Recombinant Negative for Endothelial Cell Adhesion Molecules In Vivo (Athens, Greece). Jan-Feb, 2004 | Pubmed ID: 15011745 Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-induced Cellular Damage Radiation Research. Nov, 2003 | Pubmed ID: 14565825 Overexpression of the Transgene for Manganese Superoxide Dismutase (MnSOD) in 32D Cl 3 Cells Prevents Apoptosis Induction by TNF-alpha, IL-3 Withdrawal, and Ionizing Radiation Experimental Hematology. Jun, 2003 | Pubmed ID: 12829021 Manganese Superoxide Dismutase-plasmid/liposome (MnSOD-PL) Intratracheal Gene Therapy Reduction of Irradiation-induced Inflammatory Cytokines Does Not Protect Orthotopic Lewis Lung Carcinomas In Vivo (Athens, Greece). Jan-Feb, 2003 | Pubmed ID: 12655784 Bone Marrow Origin of Myofibroblasts in Irradiation Pulmonary Fibrosis American Journal of Respiratory Cell and Molecular Biology. Aug, 2003 | Pubmed ID: 12649121 Prevention of Radiation-induced Oral Cavity Mucositis by Plasmid/liposome Delivery of the Human Manganese Superoxide Dismutase (SOD2) Transgene Radiation Research. Mar, 2003 | Pubmed ID: 12600239 Manganese Superoxide Dismutase (SOD2) Inhibits Radiation-induced Apoptosis by Stabilization of the Mitochondrial Membrane Radiation Research. May, 2002 | Pubmed ID: 11966323 Radioprotection of Lung and Esophagus by Overexpression of the Human Manganese Superoxide Dismutase Transgene Military Medicine. Feb, 2002 | Pubmed ID: 11873523 Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis Yusuf Surucu*1, Fuat Baris Bengur*1, Katherine S. Yang1, Benjamin K. Schilling1, Jocelyn S. Baker1, Sheeba Shabbir2, Renee Fisher3, Michael W. Epperly3, Joel S. Greenberger3, J. Peter Rubin1, Asim Ejaz1 1Department of Plastic Surgery, University of Pittsburgh, 2Department of Forensic Medicine and Toxicology, HBS Medical and Dental College, 3Department of Radiation Oncology, University of Pittsburgh Cancer Institute JoVE 64251 Cancer Research
Establishment of a Robust and Reproducible Model of Radiation-Induced Skin and Muscle Fibrosis Yusuf Surucu*1, Fuat Baris Bengur*1, Katherine S. Yang1, Benjamin K. Schilling1, Jocelyn S. Baker1, Sheeba Shabbir2, Renee Fisher3, Michael W. Epperly3, Joel S. Greenberger3, J. Peter Rubin1, Asim Ejaz1 1Department of Plastic Surgery, University of Pittsburgh, 2Department of Forensic Medicine and Toxicology, HBS Medical and Dental College, 3Department of Radiation Oncology, University of Pittsburgh Cancer Institute JoVE 64251 Cancer Research