Stephen Kadlecek

Publications

• Simultaneous Quantification of Hyperpolarized Xenon-129 Ventilation and Gas Exchange with Multi-breath Xenon-polarization Transfer Contrast (XTC) MRI
  Magnetic Resonance in Medicine. Dec, 2023  |   Pubmed ID: 37533368
• Preclinical MRI Using Hyperpolarized Xe
  Molecules (Basel, Switzerland). Nov, 2022  |   Pubmed ID: 36500430
• Investigating the Impact of RF Saturation-pulse Parameters on Compartment-selective Gas-phase Depolarization with Xenon Polarization Transfer Contrast MRI
  Magnetic Resonance in Medicine. Dec, 2022  |   Pubmed ID: 36046917
• Imatinib Alleviates Lung Injury and Prolongs Survival in Ventilated Rats
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2022  |   Pubmed ID: 35438574
• Simultaneous Imaging of Ventilation and Gas Exchange with Hyperpolarized Xe MRI for Monitoring Patients with Endobronchial Valve Interventions
  American Journal of Respiratory and Critical Care Medicine. May, 2022  |   Pubmed ID: 35044897
• Hyperpolarized Xe MRI of the Rat Brain with Chemical Shift Saturation Recovery and Spiral-IDEAL Readout
  Magnetic Resonance in Medicine. Apr, 2022  |   Pubmed ID: 34841605
• Deriving Regionally Specific Biomarkers of Emphysema and Small Airways Disease Using Variable Threshold Parametric Response Mapping on Volumetric Lung CT Images
  Academic Radiology. Feb, 2022  |   Pubmed ID: 34272162
• Radial Flow Perfusion Enables Real-Time Profiling of Cellular Metabolism at Low Oxygen Levels with Hyperpolarized C NMR Spectroscopy
  Metabolites. Aug, 2021  |   Pubmed ID: 34564392
• Ventilation Heterogeneity Imaged by Multibreath Wash-ins of Hyperpolarized He and Xe in Healthy Rabbits
  The Journal of Physiology. Sep, 2021  |   Pubmed ID: 34256417
• Diminishing Efficacy of Prone Positioning With Late Application in Evolving Lung Injury
  Critical Care Medicine. Apr, 2021  |   Pubmed ID: 33938714
• Measuring Pulmonary Gas Exchange Using Compartment-selective Xenon-polarization Transfer Contrast (XTC) MRI
  Magnetic Resonance in Medicine. May, 2021  |   Pubmed ID: 33283943
• Metabolic Imaging and Biological Assessment: Platforms to Evaluate Acute Lung Injury and Inflammation
  Frontiers in Physiology. 2020  |   Pubmed ID: 32982768
• Positional Therapy and Regional Pulmonary Ventilation
  Anesthesiology. Nov, 2020  |   Pubmed ID: 32773690
• Pulmonary Pyruvate Metabolism As an Index of Inflammation and Injury in a Rat Model of Acute Respiratory Distress Syndrome
  NMR in Biomedicine. Nov, 2020  |   Pubmed ID: 32681670
• Investigating Biases in the Measurement of Apparent Alveolar Septal Wall Thickness with Hyperpolarized 129Xe MRI
  Magnetic Resonance in Medicine. Dec, 2020  |   Pubmed ID: 32557808
• Computational Pipeline for Estimation of Small-molecule T1 Relaxation Times
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). May, 2020  |   Pubmed ID: 32339979
• Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy
  Hepatology (Baltimore, Md.). Jul, 2020  |   Pubmed ID: 31553806
• Detection of Lung Transplant Rejection in a Rat Model Using Hyperpolarized [1- C] Pyruvate-based Metabolic Imaging
  NMR in Biomedicine. Aug, 2019  |   Pubmed ID: 31112351
• Quantification of Ventilation and Gas Uptake in Free-Breathing Mice With Hyperpolarized Xe MRI
  IEEE Transactions on Medical Imaging. Sep, 2019  |   Pubmed ID: 30990426
• Measurement of Regional 2D Gas Transport Efficiency in Rabbit Lung Using Hyperpolarized 129Xe MRI
  Scientific Reports. Feb, 2019  |   Pubmed ID: 30787357
• Multibreath Hyperpolarized He Imaging Scheme to Measure Alveolar Oxygen Tension and Apparent Diffusion Coefficient
  Academic Radiology. Mar, 2019  |   Pubmed ID: 30630659
• Assessment of Flip Angle-TR Equivalence for Standardized Dissolved-phase Imaging of the Lung with Hyperpolarized 129Xe MRI
  Magnetic Resonance in Medicine. Mar, 2019  |   Pubmed ID: 30346083
• A Model for Predicting Future FEV1 Decline in Smokers Using Hyperpolarized He Magnetic Resonance Imaging
  Academic Radiology. Mar, 2019  |   Pubmed ID: 30087068
• Assessment of Pulmonary Gas Transport in Rabbits Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging
  Scientific Reports. May, 2018  |   Pubmed ID: 29743565
• Rapid Assessment of Pulmonary Gas Transport with Hyperpolarized 129Xe MRI Using a 3D Radial Double Golden-means Acquisition with Variable Flip Angles
  Magnetic Resonance in Medicine. Dec, 2018  |   Pubmed ID: 29682792
• Lung Metabolism and Inflammation During Mechanical Ventilation; An Imaging Approach
  Scientific Reports. Feb, 2018  |   Pubmed ID: 29476083
• Unstable Inflation Causing Injury. Insight from Prone Position and Paired Computed Tomography Scans
  American Journal of Respiratory and Critical Care Medicine. Jul, 2018  |   Pubmed ID: 29420904
• Quantifying Reaction Kinetics of the Non-enzymatic Decarboxylation of Pyruvate and Production of Peroxymonocarbonate with Hyperpolarized C-NMR
  Physical Chemistry Chemical Physics : PCCP. Jul, 2017  |   Pubmed ID: 28703828
• Tidal Changes on CT and Progression of ARDS
  Thorax. Nov, 2017  |   Pubmed ID: 28634220
• Hyperpolarized Gas Diffusion MRI of Biphasic Lung Inflation in Short- and Long-term Emphysema Models
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2017  |   Pubmed ID: 28473321
• In Vivo Imaging of the Progression of Acute Lung Injury Using Hyperpolarized [1- C] Pyruvate
  Magnetic Resonance in Medicine. Dec, 2017  |   Pubmed ID: 28074497
• A Hybrid Multibreath Wash-in Wash-out Lung Function Quantification Scheme in Human Subjects Using Hyperpolarized He MRI for Simultaneous Assessment of Specific Ventilation, Alveolar Oxygen Tension, Oxygen Uptake, and Air Trapping
  Magnetic Resonance in Medicine. Aug, 2017  |   Pubmed ID: 27734519
• In Vivo PH Mapping of Injured Lungs Using Hyperpolarized [1- C]pyruvate
  Magnetic Resonance in Medicine. Sep, 2017  |   Pubmed ID: 27714832
• The Use of Hyperpolarized Carbon-13 Magnetic Resonance for Molecular Imaging
  Advanced Drug Delivery Reviews. Apr, 2017  |   Pubmed ID: 27599979
• Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging
  Radiology. Jun, 2016  |   Pubmed ID: 26785042
• Mild Loss of Lung Aeration Augments Stretch in Healthy Lung Regions
  Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2016  |   Pubmed ID: 26662053
• Visualizing the Propagation of Acute Lung Injury
  Anesthesiology. Jan, 2016  |   Pubmed ID: 26536308
• Multibreath Alveolar Oxygen Tension Imaging
  Magnetic Resonance in Medicine. Oct, 2016  |   Pubmed ID: 26467179
• Low-temperature Dynamic Nuclear Polarization of Gases in Frozen Mixtures
  Magnetic Resonance in Medicine. Sep, 2016  |   Pubmed ID: 26444315
• Versatile Pulse Sequence Device to Conserve Hyperpolarization for NMR and MRI Studies
  Magnetic Resonance in Medicine. Apr, 2016  |   Pubmed ID: 25976973
• Ascorbic Acid Prolongs the Viability and Stability of Isolated Perfused Lungs: A Mechanistic Study Using 31P and Hyperpolarized 13C Nuclear Magnetic Resonance
  Free Radical Biology & Medicine. Dec, 2015  |   Pubmed ID: 26165188
• Oxygen-weighted Hyperpolarized (3)He MR Imaging: A Short-term Reproducibility Study in Human Subjects
  Radiology. Oct, 2015  |   Pubmed ID: 26110668
• Semiautomatic Segmentation of Longitudinal Computed Tomography Images in a Rat Model of Lung Injury by Surfactant Depletion
  Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2015  |   Pubmed ID: 25640150
• Efficient Production of Hyperpolarized Bicarbonate by Chemical Reaction on a DNP Precursor to Measure PH
  Magnetic Resonance in Medicine. Nov, 2015  |   Pubmed ID: 25393101
• Alterations of Regional Alveolar Oxygen Tension in Asymptomatic Current Smokers: Assessment with Hyperpolarized (3)He MR Imaging
  Radiology. Feb, 2015  |   Pubmed ID: 25322340
• Vertical Gradients in Regional Alveolar Oxygen Tension in Supine Human Lung Imaged by Hyperpolarized 3He MRI
  NMR in Biomedicine. Dec, 2014  |   Pubmed ID: 25395184
• The Effect of Exogenous Substrate Concentrations on True and Apparent Metabolism of Hyperpolarized Pyruvate in the Isolated Perfused Lung
  NMR in Biomedicine. Dec, 2014  |   Pubmed ID: 25330438
• Hyperpolarized Gas Diffusion MRI for the Study of Atelectasis and Acute Respiratory Distress Syndrome
  NMR in Biomedicine. Dec, 2014  |   Pubmed ID: 24920074
• Metabolic Spectroscopy of Inflammation in a Bleomycin-induced Lung Injury Model Using Hyperpolarized 1-(13) C Pyruvate
  NMR in Biomedicine. Aug, 2014  |   Pubmed ID: 24865640
• Regional Alveolar Partial Pressure of Oxygen Measurement with Parallel Accelerated Hyperpolarized Gas MRI
  Academic Radiology. Oct, 2013  |   Pubmed ID: 24029054
• Positive End-expiratory Pressure Increments During Anesthesia in Normal Lung Result in Hysteresis and Greater Numbers of Smaller Aerated Airspaces
  Anesthesiology. Dec, 2013  |   Pubmed ID: 24025616
• Accelerated Fractional Ventilation Imaging with Hyperpolarized Gas MRI
  Magnetic Resonance in Medicine. Nov, 2013  |   Pubmed ID: 23400938
• A Variability Study of Regional Alveolar Oxygen Tension Measurement in Humans Using Hyperpolarized (3) He MRI
  Magnetic Resonance in Medicine. Dec, 2013  |   Pubmed ID: 23382040
• Imaging the Interaction of Atelectasis and Overdistension in Surfactant-depleted Lungs
  Critical Care Medicine. Feb, 2013  |   Pubmed ID: 23263577
• Determination of the Singlet State Lifetime of Dissolved Nitrous Oxide from High Field Relaxation Measurements
  The Journal of Chemical Physics. May, 2012  |   Pubmed ID: 22583250
• Multislice Fractional Ventilation Imaging in Large Animals with Hyperpolarized Gas MRI
  NMR in Biomedicine. Sep, 2012  |   Pubmed ID: 22290603
• A Multislice Single Breath-hold Scheme for Imaging Alveolar Oxygen Tension in Humans
  Magnetic Resonance in Medicine. May, 2012  |   Pubmed ID: 22190347
• Regional Function-structure Relationships in Lungs of an Elastase Murine Model of Emphysema
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2012  |   Pubmed ID: 21940853
• A Simple and Low-cost Device for Generating Hyperpolarized Contrast Agents Using Parahydrogen
  NMR in Biomedicine. Oct, 2011  |   Pubmed ID: 21845739
• Regional Determination of Oxygen Uptake in Rodent Lungs Using Hyperpolarized Gas and an Analytical Treatment of Intrapulmonary Gas Redistribution
  NMR in Biomedicine. Dec, 2011  |   Pubmed ID: 21387449
• Quantitative Imaging of Alveolar Recruitment with Hyperpolarized Gas MRI During Mechanical Ventilation
  Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2011  |   Pubmed ID: 21127207
• Regional Correlation of Emphysematous Changes in Lung Function and Structure: a Comparison Between Pulmonary Function Testing and Hyperpolarized MRI Metrics
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2011  |   Pubmed ID: 20884833
• Quantitative Assessment of Lung Ventilation and Microstructure in an Animal Model of Idiopathic Pulmonary Fibrosis Using Hyperpolarized Gas MRI
  Academic Radiology. Nov, 2010  |   Pubmed ID: 20934126
• Optimal Transfer of Spin-order Between a Singlet Nuclear Pair and a Heteronucleus
  Journal of Magnetic Resonance (San Diego, Calif. : 1997). Jul, 2010  |   Pubmed ID: 20427216
• Improved Technique for Measurement of Regional Fractional Ventilation by Hyperpolarized 3He MRI
  Magnetic Resonance in Medicine. Jan, 2010  |   Pubmed ID: 19877277
• Quantitative Assessment of Lung Using Hyperpolarized Magnetic Resonance Imaging
  Proceedings of the American Thoracic Society. Aug, 2009  |   Pubmed ID: 19687215
• Simultaneous Measurement of Pulmonary Partial Pressure of Oxygen and Apparent Diffusion Coefficient by Hyperpolarized 3He MRI
  Magnetic Resonance in Medicine. May, 2009  |   Pubmed ID: 19230017
• A Robust Method for Estimating Regional Pulmonary Parameters in Presence of Noise
  Academic Radiology. Jun, 2008  |   Pubmed ID: 18486010
• Measurement of Pulmonary Partial Pressure of Oxygen and Oxygen Depletion Rate with Hyperpolarized Helium-3 MRI: a Preliminary Reproducibility Study on Pig Model
  Academic Radiology. Jun, 2008  |   Pubmed ID: 18486007
• Early Changes of Lung Function and Structure in an Elastase Model of Emphysema--a Hyperpolarized 3He MRI Study
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2008  |   Pubmed ID: 18063806
• Optimization of Scan Parameters in Pulmonary Partial Pressure Oxygen Measurement by Hyperpolarized 3He MRI
  Magnetic Resonance in Medicine. Jan, 2008  |   Pubmed ID: 18050348
• Multiple Regression Method for Pulmonary Apparent Diffusion Coefficient Measurement by Hyperpolarized 3He MRI
  Journal of Magnetic Resonance Imaging : JMRI. May, 2007  |   Pubmed ID: 17457799
• Measurements of Regional Alveolar Oxygen Pressure Using Hyperpolarized 3He MRI
  Academic Radiology. Nov, 2005  |   Pubmed ID: 16253855
• Hyperpolarized 3He MRI in Asthma Measurements of Regional Ventilation Following Allergic Sensitization and Challenge in Mice--preliminary Results
  Academic Radiology. Nov, 2005  |   Pubmed ID: 16253848