Gastric Artery Ligation
Gastric Artery Ligation - Related Videos
05:47
Modified Technique for Coronary Artery Ligation in Mice
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Cited by 8 •
2013
The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.
07:41
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
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Cited by 47 •
2011
Numerous genetic manipulations and/or intramyocardial injections of genes, proteins, cells, and/or biomaterials are superimposed upon the dimension of time in studies of acute ischemia/ reperfusion injury and chronic remodeling in mice. This video illustrates the microsurgical procedures for ischemia/reperfusion, permanent coronary artery ligation, and intramyocardial injection studies.
08:27
The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
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Cited by 29 •
2011
Middle cerebral artery (MCA) ligation is a technique to study focal cerebral ischemia in animal models. In this method, the middle cerebral artery is exposed by craniotomy and ligated by cauterization. This method gives highly reproducible infarct volumes and increased post-operative survival rates compared to other methods available.
03:17
An Experimental Model of Peripheral Ischemia: A Procedure to Generate Peripheral Ischemia via Femoral Artery Ligation in a Rabbit
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2025
In this video, we demonstrate a surgical procedure to induce peripheral ischemia via femoral artery ligation in a rabbit. This method provides an effective experimental model for peripheral vascular disease research.
05:18
Roux-en-Y Gastric Bypass Procedure: A Bariatric Surgical Procedure for Gastric Resectioning in Murine Model
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2025
This video describes a bariatric surgery-Roux-en-Y procedure. This involves the cutting of the jejunum- the middle portion of the intestine- to generate two intestinal limbs. The biliary limb is attached to the existing intestinal loop and the alimentary limb is attached to the stomach, creating a gastric bypass. The gastric bypass created here helps to decrease the nutrient uptake and efficiently reduces body weight.
FAQs
Interrupting arterial perfusion reduces the delivery of oxygen and nutrients to gastric tissue and nearby tumor regions. This altered supply can produce ischemia, meaning inadequate blood flow relative to tissue needs, and allows researchers to examine subsequent tissue responses. The resulting changes help connect vascular supply with local gastric and tumor biology.
The artery selected for ligation determines which regions experience the strongest reduction in perfusion. Occluding one vessel or several vessels can therefore create different patterns of vascular disruption in the stomach and nearby tumor tissue. Comparing these conditions helps researchers evaluate how the extent and location of arterial interruption affect oxygen availability, nutrient access, and tissue response.
Ischemia provides a way to investigate how tumor-associated tissue responds when blood flow becomes limited. Reduced oxygen and nutrient availability can be examined alongside changes in gastric tissue and nearby tumors, linking local perfusion with tumor vascularization. This is relevant to cancer research because vascular conditions may influence tumor biology and the response to treatments that affect perfusion.
A typical workflow identifies the gastric artery or arteries selected for study, places a ligature around the targeted vessel, and interrupts arterial perfusion. Researchers then assess the effects of reduced blood flow on gastric tissue and nearby tumors. The exact vessels and evaluation procedures depend on the experimental question, but the ligation establishes the intended vascular perturbation.
Post-ligation assessment can reveal how reduced arterial supply changes oxygen delivery, nutrient availability, ischemia, and tissue response. In cancer studies, these observations can also inform analysis of tumor vascularization and gastrointestinal tumor biology. The method is therefore useful for connecting a controlled change in blood flow with measurable responses in both normal gastric tissue and nearby tumors.
Researchers use gastric artery ligation as an experimental model when they need to examine relationships between blood supply and gastrointestinal tumors. It can support studies of tumor vascularization, vascular mechanisms, and therapies that influence tumor perfusion. Because it directly alters arterial supply, the approach helps evaluate how changes in perfusion may relate to treatment response.