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In vivo Biosensor Tracks Ikke-apoptotisk Caspase aktivitet i Drosophila

Article DOI: 10.3791/53992-v • 13:21 min • November 27th, 2016
November 27th, 2016 •
1, 1, 2, 1
1W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, 2School of Life Sciences, Chinese University of Hong Kong

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For at detektere sunde celler i hele dyr, der indeholder lave niveauer af caspaseaktivitet, blev den meget følsomme biosensor betegnet CaspaseTracker genereret for Drosophila. Caspase-afhængige biosensor aktivitet detekteres i langlivede raske celler i hele de indre organer af voksne dyr, der er opdrættet under optimerede betingelser i fravær af død stimuli.

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Molekylærbiologi Caspase biosensor, apoptose ikke-apoptotiske hjerne neuroner CaspaseTracker
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