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JoVE Journal Biochemistry
Methode voor het identificeren van kleinmoleculige remmers van het eiwit-eiwit interactie tussen HCN1 en TRIP8b
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Methode voor het identificeren van kleinmoleculige remmers van het eiwit-eiwit interactie tussen HCN1 en TRIP8b

Article DOI: 10.3791/54540-v • 10:20 min • November 11th, 2016
November 11th, 2016 •
*1, *1, 2, 3, 1, 1, 4, 1,5
1Davee Department of Neurology and Clinical Neurosciences, Feinberg School of Medicine, Northwestern University, 2Center for Molecular Innovation and Drug Discovery, Northwestern University, 3Department of Pharmacology, Feinberg School of Medicine, Northwestern University, 4High Throughput Analysis Laboratory, Department of Molecular Biosciences, Northwestern University, 5Department of Physiology, Feinberg School of Medicine, Northwestern University
* These authors contributed equally

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De interactie tussen HCN kanalen en hun ondersteunende subunit is geïdentificeerd als een therapeutisch doel in depressieve stoornis. Hier wordt een fluorescentie-polarisatie- methode voor het identificeren van kleinmoleculige remmers van dit eiwit-eiwit interactie, gepresenteerd.

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Biochemistry High-throughput screening drug discovery eiwit-eiwit interacties fluorescentiepolarisatie HCN TRIP8b
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