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Convection Enhanced Delivery of Optogenetic Adeno-associated Viral Vector to the Cortex of Rhesus Macaque Under Guidance of Online MRI Images

Article DOI: 10.3791/59232-v • 08:52 min • May 23rd, 2019
May 23rd, 2019 •
1,2, 2,3, 4, 1,2,3,4
1Departments of Bioengineering, University of Washington, 2Washington National Primate Research Center, 3Department of Electrical and Computer Engineering, University of Washington, 4Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco

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Here, we demonstrate magnetic resonance (MR)-guided convection enhanced delivery (CED) of viral vectors into the cortex as an efficient and simplified approach for achieving optogenetic expression across large cortical areas in the macaque brain.

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Convection Enhanced Delivery CED Optogenetic Viral Vectors Non Human Primates Neural Activity Manipulation Large-scale Neural Computations Behaviors High Optogenetic Expression Few Injections Short Amount Of Time Traditional Methods Magnetic Resonance Imaging MRI Images MR Compatible Chamber Implantation Non Human Primate Surgeries Circular Craniotomy Trephine Skull Indentation Bone Cap Removal Dura Cutting
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