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Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart

Article DOI: 10.3791/62833-v • 06:07 min • September 2nd, 2021
September 2nd, 2021 •
1, 1, 1
1A.I. Virtanen Institute, University of Eastern Finland

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Myocardial gene therapy for ischemic heart disease holds great promise for future therapeutics. Here, we introduce a large animal model for evaluating the efficacy of gene therapy in the ischemic heart.

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Large Animal Model Efficacy Gene Therapy Ischemic Heart Imaging Modalities Safety Clinical Trials Invasiveness Targeting Hypokinetic Areas Transthoracic Echocardiography Ischemia Operation Gene Transfer Euthanasia Pericardial Fluid Myocardial Strain Transducer Intercostal Space Parasternal Short Axis Views Mitral Valve Level Papillary Muscle Apical Levels Coronary Angiography Fluoroscopic Guidance Iodine Contrast Agent Right Coronary Artery Left Ascending Coronary Artery Left Anterior Descending Artery Cine Imaging
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