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Genetics
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JoVE Journal Genetics
En protokol til evaluering og kvantificering af retinale pigmenterede epitelpatologier i musemodeller af aldersrelateret makuladegeneration
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En protokol til evaluering og kvantificering af retinale pigmenterede epitelpatologier i musemodeller af aldersrelateret makuladegeneration

Article DOI: 10.3791/64927-v • 09:24 min • March 10th, 2023
March 10th, 2023 •
1,2, 1, 3, 1,2, 3,4, 1,2
1Department of Medical Genetics, University of Wisconsin-Madison, 2McPherson Eye Research Institute, University of Wisconsin-Madison, 3Department of Ophthalmology, Duke University, 4Department of Cell Biology, Duke University

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Musemodeller kan være nyttige værktøjer til at undersøge biologien af det retinale pigmenterede epitel (RPE). Det er blevet fastslået, at mus kan udvikle en række RPE-patologier. Her beskriver vi en fænotypeprotokol til belysning og kvantificering af RPE-patologier hos mus ved hjælp af lys, transmissionselektron og konfokal mikroskopi.

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Denne måned i JoVE nummer 193
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