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Biochemistry

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JoVE Journal Biochemistry

A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development (Video) | JoVE

Hybrid Clear/Blue Native Electrophoresis for the Separation and Analysis of Mitochondrial Respiratory Chain Supercomplexes

Journal (Biochemistry)

Hybrid Clear/Blue Native Electrophoresis for the Separation and Analysis of Mitochondrial Respiratory Chain Supercomplexes

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species

Journal (Biochemistry)

Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species

A Bicelle Crystallization Setup for ABC Transporter Membrane Proteins to Advance Drug Development (Video) | JoVE

Crystallization of ABC Transporter Membrane Proteins in Lipidic Bicelles

Article DOI: 10.3791/65828-v • 01:55 min • August 25th, 2023

August 25th, 2023 •

Sarah Wazir¹, Danny Farhat¹, Mahalashmi Srinivasan^1,2, Jyh-Yeuan Lee¹

¹Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, ²Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta

Tags

ABCG5/G8 Lipidic Bicelle X-ray Crystallography Membrane Proteins Lipid Bilayer Detergents Stability Uniformity Structural Characterization Bicelles Phospholipids High-quality Diffraction Crystals High-resolution Structure Native Conformation Functionality Three-dimensional Crystals Detergent-solubilized Heterodimeric ABCG5/G8 DMPC/CHAPSO Bicelles Cholesterol Vapor Diffusion Protein Crystallization

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