China Clinical Research Center for Epilepsy Capital Medical University 1 article published in JoVE Neuroscience Using a Bipolar Electrode to Create a Temporal Lobe Epilepsy Mouse Model by Electrical Kindling of the Amygdala Yongchang Lu*1,2, Yang Dai*1,2, Siqi Ou1,2, Yujing Miao1, Ying Wang1,2, Quanlei Liu1,2, Yihe Wang1,2, Penghu Wei1,2, Yongzhi Shan1,2, Guoguang Zhao1,2,3 1Department of Neurosurgery, Xuanwu Hospital Capital Medical University, 2China Clinical Research Center for Epilepsy Capital Medical University, 3China Beijing Municipal Geriatric Medical Research Center The amygdala plays a key role in temporal lobe epilepsy, which originates in and propagates from this structure. This article provides a detailed description of the fabrication of deep brain electrodes with both recording and stimulating functions. It introduces a model of medial temporal lobe epilepsy originating from the amygdala.
