GmbH 1 article published in JoVE Chemistry A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients Sharareh Salar-Behzadi1,2, Carolina Corzo1, Peter Laggner1 1Research Center Pharmaceutical Engineering, GmbH, 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Technology and Biopharmacy, University of Graz This publication shows the application of x-ray diffraction and differential scanning calorimetry as gold standards for investigating the solid-state of lipid-based excipients (LBEs). Understanding the solid-state alteration in LBEs and its effect on the performance of pharmaceutical products thereof is the key factor for manufacturing robust lipid-based dosage forms.