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Cancer Research

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JoVE Journal Cancer Research
Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Article DOI: 10.3791/58056-v • 05:32 min • January 7th, 2019
January 7th, 2019 •
1, 2, 3, 3, 1,3, 4, 1, 1,3
1Greater Los Angeles Veteran Administration Healthcare System, 2San Diego Veterans Administration Healthcare System, 3University of California, Los Angeles, 4Perkin Elmer

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Summary
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Here we use bioluminescent, X-ray, and positron-emission tomography/computed tomography imaging to study how inhibiting mTOR activity impacts bone marrow-engrafted myeloma tumors in a xenograft model. This allows for physiologically relevant, non-invasive, and multimodal analyses of the anti-myeloma effect of therapies targeting bone marrow-engrafted myeloma tumors in vivo.

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Multimodal Bioluminescent Positronic-emission Tomography Computational Tomography Multiple Myeloma Bone Marrow Xenografts NOG Mice Bone Marrow Micro-environment Engrafted Myeloma Tumors Anti-drug Studies Biochemical Pathways Non-invasive Luciferase Transfected Cells PBS Centrifugation Anesthetized Mouse Ophthalmic Ointment Insulin Syringe Tail Vein Injection Recovery Monitoring In Vivo Grade D-luciferin Substrate Sterile Saline Intraperitoneally Small Animal Imaging System
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