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JoVE Journal Medicine
Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Article DOI: 10.3791/58057-v • 07:41 min • March 17th, 2022
March 17th, 2022 •
1, 1,2, 1, 1, 3, 4, 5, 1, 1, 2, 1
1Research and Innovation Unit, RHU BioArt Lung 2020, Marie Lannelongue Hospital, 2Phenotypic and Biomarker Core Laboratory, Cardiovascular Institute, Stanford University, 3Department of pathology, Marie Lannelongue Hospital, 4Department of pathology, UCSF School of Medicine, 5Department of thoracic surgery, Hopital Nord, APHM, Aix-Marseille University

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Summary
Automatic Translation

We present a protocol to induce and phenotype an acute right heart failure in a large animal model with chronic pulmonary hypertension. This model can be used to test therapeutic interventions, to develop right heart metrics or to improve the understanding of acute right heart failure pathophysiology.

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Induction Phenotyping Acute Right Heart Failure Large Animal Model Chronic Thromboembolic Pulmonary Hypertension Pathophysiology Volume Overload Pressure Overload Central Venous Catheter Seldinger Method Transverse Incision Groin Beckman Retractor Debakey Forceps Metzenbaum Scissors Femoral Vein Femoral Artery 20 Gauge Catheter Disposable Transducer Systemic Blood Pressure Central Venous Blood Pressure 18 Gauge Catheter Fluoroscope C-arm Guidewire Balloon Dilation Catheter Intrapericardial Level Diaphragm Level
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