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Journal / Biochemistry / 基于荧光的连续核酸内切酶偶联DNA甲基化测定，用于筛选DNA甲基转移酶抑制剂…
JoVE Journal
Biochemistry

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JoVE Journal Biochemistry
基于荧光的连续核酸内切酶偶联DNA甲基化测定，用于筛选DNA甲基转移酶抑制剂
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基于荧光的连续核酸内切酶偶联DNA甲基化测定，用于筛选DNA甲基转移酶抑制剂

Article DOI: 10.3791/62949-v • 06:07 min • August 5th, 2022
August 5th, 2022 •
1, 2, 2
1Department of Chemistry, Bucknell University, 2Program in Cell Biology/Biochemistry, Bucknell University

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DNA甲基转移酶是潜在的癌症药物靶标。在这里，提出了一个协议来评估DNA甲基转移酶抑制的小分子。该测定利用核酸内切酶将DNA甲基化与荧光生成偶联，并允许实时监测酶活性。

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生物化学， 第186期， 生物化学， 问题，
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