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Pathology Assessment of PN-MPNST Progression in the P0-GGFβ3 Mouse Model

May 17th, 2024
1, 1,2, 1, 1,2
1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2Hollings Cancer Center, Medical University of South Carolina

Summary
Automatic Translation

We have developed a methodology for assessing whether nervous system neoplasms in genetically engineered mice accurately recapitulate the pathology of their human counterparts. Here, we apply these histologic techniques, defined pathologic criteria, and culture methodologies to neurofibromas and malignant peripheral nerve sheath tumors arising in the P0-GGFβ3 mouse model.

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