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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Article DOI: 10.3791/51485-v • 12:11 min • April 29th, 2014
April 29th, 2014 •
1, 1, 2, 1, 1
1Genitourinary Section, Department of Medicine, Roswell Park Cancer Institute, 2Biological Sciences Platform, Sunnybrook Research Institute

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Models of spontaneous metastatic renal cell carcinoma (RCC) disease progression can be used for evaluating treatments in a clinically relevant setting. This protocol demonstrates different procedures for orthotopic kidney tumor cell implantation, proper nephrectomy, and finally outlines a necropsy guide for visual and bioluminescent scoring of metastatic burden and localization.

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Metastatic Renal Cell Carcinoma MRCC Mice Model Nephrectomy Experimental Therapeutics Tumor Implantation Models Spontaneous Metastatic Disease Orthotopic Tumor Cell Implantation Syngeneic Model Matrigel Tumor-bearing Kidney Excision Surgical Mouse Care Micro-metastatic Disease Progression Macro-metastatic Disease Progression Bioluminescent Imaging Necropsy Guide Systemic Disease Distribution Therapeutic Testing
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