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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus
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Stereotaxic Infusion of Oligomeric Amyloid-beta into the Mouse Hippocampus

Article DOI: 10.3791/52805-v • 08:16 min • June 17th, 2015
June 17th, 2015 •
1, 2, 2, 1,2, 1,2,3
1Department of Pathology and Cell Biology, Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 3Department of Neurology, Columbia University Medical Center

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Here, we present a protocol for direct stereotaxic brain infusion of amyloid-beta. This methodology provides an alternative in vivo mouse model to address the short-term effects of amyloid-beta on brain neurons.

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Stereotaxic Infusion Oligomeric Amyloid-beta Mouse Hippocampus Alzheimer's Disease Neurodegenerative Disease Amyloid-beta Over-production Amyloid-beta Plaques Alzheimer's Disease Mouse Models Neuronal Death Soluble Oligomeric Species Of Amyloid-beta Surgical Technique Dentate Gyrus Hippocampus Neuron Loss Cell Death Cholinergic Neuron
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