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Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Article DOI: 10.3791/53318-v • 09:02 min • December 10th, 2015
December 10th, 2015 •
1, 1, 1
1Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine

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Nuclear envelope proteins play a central role in many basic biological processes and have been implicated in a variety of human diseases. This protocol describes a new Cre/Lox-based mouse model that allows for the spatiotemporal control of LINC complexes disruption.

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Mouse Model LINC Complexes Nuclear Migration Anchorage Macromolecular Protein Assemblies Sun Proteins Nesprins SUN Domain KASH Domain Nuclear Lamina Perinuclear Space Cytoskeleton Dominant-negative Transgenic Mouse Strategy Cre/Lox System Cell-type Specific Manner Germline Models Of LINC Complex Inactivation
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