Landesdirektion Sachsen 1 article published in JoVE Neuroscience In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation Nereo Kalebic1,2, Barbara Langen1,3, Jussi Helppi1, Hiroshi Kawasaki4, Wieland B. Huttner1 1Max Planck Institute of Molecular Cell Biology and Genetics, 2Human Technopole, 3Landesdirektion Sachsen, 4Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University Presented here is a protocol to perform genetic manipulation in the embryonic ferret brain using in utero electroporation. This method allows for targeting of neural progenitor cells in the neocortex in vivo.