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Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Article DOI: 10.3791/2241-v • 12:06 min • May 12th, 2011
May 12th, 2011 •
*1, *1, 1
1Department of Surgery, University of Toronto
* These authors contributed equally

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Optic Nerve transection is a widely used model of adult CNS injury. Ninety percent of retinal ganglion cells (RGCs) whose axons are completely transected (axotomy) die within 14 days after axotomy. This model is easily amenable to experimental manipulations and highly reproducible.

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Optic Nerve Transection Adult Neuron Apoptosis Central Nervous System Retinal Ganglion Cells Optic Nerve Axotomized Apoptotic Neuronal Cell Death CNS Model Vitreous Chamber Drug Delivery Intraocular Injections Short Interfering RNAs (siRNAs) Plasmids Viral Vectors Superior Colliculus Apoptotic Mechanisms Neuronal Population Cell Survival Quantification Fluorescent Tracer
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