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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
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Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia

Article DOI: 10.3791/52728-v • 10:35 min • September 20th, 2015
September 20th, 2015 •
1, 1, 1,2, 3, 3, 1,4
1Department of Biomedical Engineering, University of California, Davis, 2Nuclear Magnetic Resonance Facility, University of California, Davis, 3Biomedical Imaging, Genentech, Inc, 4Department of Radiology, University of California, Davis

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The method presented here uses simultaneous positron emission tomography and magnetic resonance imaging. In the cerebral hypoxia-ischemia model, dynamic changes in diffusion and glucose metabolism occur during and after injury. The evolving and irreproducible damage in this model necessitates simultaneous acquisition if meaningful multi-modal imaging data are to be acquired.

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PET/MRI Imaging Mouse Cerebral Hypoxia-ischemia Tissue Water Diffusion Glucose Metabolism Diffusion Weighted MRI 2-deoxy-2-(18F)fluoro-β-glucose ([18F]FDG) Uptake Bioenergetics Disturbance Damaged Regions Hypoxic-ischemic Injury Simultaneous Data Acquisition Inter-animal Variability Multi-modal Data Analysis Physiological Changes
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