Beijing Research Center of Urban System Engineering 1 article published in JoVE Bioengineering Microfluidic Model to Mimic Initial Event of Neovascularization Ping Zhao1, Xing Zhang1, Xiao Liu1, Li Wang4, Haoran Su1, Liyi Wang1, Dongrui Zhang1, Xiaoyan Deng3, Yubo Fan1,2 1Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Chinese Education Ministry, School of Biological Science and Medical Engineering, Beihang University, 2School of Engineering Medicine, Beihang University, 3Artificial Intelligence Key Laboratory of Sichuan Province, School of Automation and Information Engineering, Sichuan University of Science and Engineering, 4Beijing Research Center of Urban System Engineering Here, we provide a microfluidic chip and an automatically controlled, highly efficient circulation microfluidic system that recapitulates the initial microenvironment of neovascularization, allowing endothelial cells (ECs) to be stimulated by high luminal shear stress, physiological level of transendothelial flow, and various vascular endothelial growth factor (VEGF) distribution simultaneously.
