Shanghai Key Laboratory of Stomatology 1 article published in JoVE Medicine Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement Yuanqi Liu*1,2,3,4,5, Siyuan Sun*1,2,3,4,5, Ziyi Jiang*6, Xinyi Gong1,2,3,4,5, Yiling Yang1,2,3,4,5, Yanfei Zhu1,2,3,4,5, Hongyuan Xu1,2,3,4,5, Anting Jin1,2,3,4,5, Xiangru Huang1,2,3,4,5, Xin Gao1,2,3,4,5, Tingwei Lu1,2,3,4,5, Jingyi Liu1,2,3,4,5, Xinyu Wang1,2,3,4,5, Qinggang Dai2,3,4,5,7, Lingyong Jiang1,2,3,4,5 1Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 2College of Stomatology, Shanghai Jiao Tong University, 3National Center for Stomatology, 4National Clinical Research Center for Oral Diseases, 5Shanghai Key Laboratory of Stomatology, 6Shanghai Starriver Bilingual School, 7The 2nd Dental Center, Ninth People’s Hospital, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine This study provides a protocol for using inducible osteoblast lineage-specific Stat3 knockout mice to study bone remodeling under orthodontic force and describes methods for analyzing alveolar bone remodeling during orthodontic tooth movement, thus shedding light on skeletal mechanical biology.
