2 articles published in JoVE
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats Qimiao Hu*1, Xiaoli Zheng*1, Ruixiang Chen1, Boyu Liu1, Yan Tai2, Xiaomei Shao1, Jianqiao Fang1, Boyi Liu1 1Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, 2Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University Provided here is a protocol that details steps to establish an animal model of chronic post-ischemia pain (CPIP). This is a well-recognized model mimicking human complex regional pain syndrome type-I. Mechanical and thermal hypersensitivities are further evaluated, as well as capsaicin-induced nocifensive behaviors observed in the CPIP rat model.
Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment Mei Wang1, Zhengluan Liao2, Dewang Mao3, Qi Zhang1, Yumei Li3, Enyan Yu2, Zhongxiang Ding3 1Zhejiang Chinese Medical University, 2 Based on resting-state functional magnetic resonance imaging with Granger causality analysis, we investigated the alterations in the directed functional connectivity between the posterior cingulate cortex and whole brain in patients with Alzheimer's Disease (AD), patients with Mild Cognitive Impairment (MCI), and healthy controls.