Yongchuan Hospital of Chongqing Medical University 1 article published in JoVE Cancer Research Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation Juan Wang1, Jin Wen2, Xiao-Xiang Chen1, Guang-Liang Chen3 1Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 2Department of Nephrology and Rheumatology, Yongchuan Hospital of Chongqing Medical University, 3Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University Here, we present a reliable and straightforward two-dimensional (2D) coculture system for studying the interaction between tumor cells and bone marrow adipocytes, which reveals a dual effect of melanoma cell-derived factors on the bone marrow adipocytes differentiation and also poses a classic method for the mechanistic study of bone metastasis.
