Nagoya University Institute for Advanced Research 1 article published in JoVE Medicine Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination Hirotoshi Yasui1, Yuko Nishinaga1, Shunichi Taki1, Kazuomi Takahashi1, Yoshitaka Isobe1, Kazuhide Sato1,2,3 1Respiratory Medicine, Nagoya University Graduate School of Medicine, 2Nagoya University Institute for Advanced Research, 3B3-Unit, Advanced Analytical and Diagnostic Imaging Center (AADIC)/Medical Engineering Unit (MEU), Nagoya University Institute for Advanced Research Near-infrared photoimmunotherapy (NIR-PIT) is an emerging cancer therapeutic strategy that utilizes an antibody-photoabsorber (IR700Dye) conjugate and NIR light to destroy cancer cells. Here, we present a method to evaluate the antitumor effect of NIR-PIT in a mouse model of pleural disseminated lung cancer and malignant pleural mesothelioma using bioluminescence imaging.
