2 articles published in JoVE
An Innovative Running Wheel-based Mechanism for Improved Rat Training Performance Chi-Chun Chen1, Chin-Lung Yang2, Ching-Ping Chang3,4 1Department of Electronic Engineering, National Chin-Yi University of Technology, 2Department of Electrical Engineering, National Cheng Kung University, 3Department of Biotechnology, Southern Taiwan University of Science and Technology, 4Department of Medical Research, Chi Mei Medical Center This study presents an innovative running wheel-based animal mobility system to quantify an effective exercise activity in rats. A rat-friendly testbed is built, using a predefined adaptive acceleration curve, and a high correlation between the effective exercise rate and the infarct volume suggests the protocol's potential for stroke prevention experiments.
Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice Wei-Ting Chang*1,2, Sudeshna Fisch*1, Michael Chen1, Yiling Qiu1, Susan Cheng1, Ronglih Liao1 1 Coronary flow reserve (CFR) is useful for assessment of myocardial oxygen demand and evaluation of cardiovascular risk. This study establishes a step-by-step transthoracic Doppler echocardiographic (TTDE) method for longitudinal monitoring of the changes in CFR, as measured from coronary artery in mice, under the experimental pressure overload of aortic banding.